BACKGROUND: Antisperm antibodies (ASA) in males cause the autoimmune disease 'immune infertility'. The mechanism of ASA cause male infertility is not clear. Present studies have investigated the effect of ASA and their incidence in men with unexplained infertility, as well as to evaluate the correlation between the ASA and semen parameter alterations but have shown inconsistent results. We performed a systematic literature review and meta-analysis to assess the association between ASA and basic semen parameters in infertility men. METHODS: Systematic literature searches were conducted with PubMed, EMBASE, Science Direct/Elsevier, CNKI and the Cochrane Library up to October 2014 for case-control studies that involved the impact of ASA on semen parameters. Meta-analysis was performed with Review Manager. Standard mean differences (SMD) of semen parameters were identified with 95% CI in a random or fixed effects model. RESULTS: Eight studies were identified, including 238 cases of ASA positive infertility male and 929 ASA negative controls. Our results illustrated that the sperm concentration and sperm motility (a+b) from ASA positive patients were significantly lower than ASA negative controls (SMD (95% CI) -23.64 [-43.47, -3.81], -16.40 [-27.92, -4.88], respectively). However, semen liquefaction time in the ASA positive group was significantly longer than the control group (SMD (95% CI) 4.19 [1.72, 6.66]). There was no significant effect of ASA on the sperm volume, sperm viability, sperm progressive motility, sperm normal morphology and sperm abnormal morphology. CONCLUSIONS: The present study illustrates that there was a significant negative effect of ASA on sperm concentration, sperm motility (a+b) and sperm liquefaction.
BACKGROUND: Antisperm antibodies (ASA) in males cause the autoimmune disease 'immune infertility'. The mechanism of ASA cause male infertility is not clear. Present studies have investigated the effect of ASA and their incidence in men with unexplained infertility, as well as to evaluate the correlation between the ASA and semen parameter alterations but have shown inconsistent results. We performed a systematic literature review and meta-analysis to assess the association between ASA and basic semen parameters in infertilitymen. METHODS: Systematic literature searches were conducted with PubMed, EMBASE, Science Direct/Elsevier, CNKI and the Cochrane Library up to October 2014 for case-control studies that involved the impact of ASA on semen parameters. Meta-analysis was performed with Review Manager. Standard mean differences (SMD) of semen parameters were identified with 95% CI in a random or fixed effects model. RESULTS: Eight studies were identified, including 238 cases of ASA positive infertility male and 929 ASA negative controls. Our results illustrated that the sperm concentration and sperm motility (a+b) from ASA positive patients were significantly lower than ASA negative controls (SMD (95% CI) -23.64 [-43.47, -3.81], -16.40 [-27.92, -4.88], respectively). However, semen liquefaction time in the ASA positive group was significantly longer than the control group (SMD (95% CI) 4.19 [1.72, 6.66]). There was no significant effect of ASA on the sperm volume, sperm viability, sperm progressive motility, sperm normal morphology and sperm abnormal morphology. CONCLUSIONS: The present study illustrates that there was a significant negative effect of ASA on sperm concentration, sperm motility (a+b) and sperm liquefaction.
Authors: A Ferlin; A E Calogero; C Krausz; F Lombardo; D Paoli; R Rago; C Scarica; M Simoni; C Foresta; V Rochira; E Sbardella; S Francavilla; G Corona Journal: J Endocrinol Invest Date: 2022-01-24 Impact factor: 4.256
Authors: Francesco Pallotti; Sandro C Esteves; Fabiana Faja; Alessandra Buonacquisto; Anna Chiara Conflitti; Maria Neve Hirsch; Andrea Lenzi; Donatella Paoli; Francesco Lombardo Journal: Endocrine Date: 2022-10-19 Impact factor: 3.925
Authors: Sajal Gupta; Rakesh Sharma; Ashok Agarwal; Florence Boitrelle; Renata Finelli; Ala'a Farkouh; Ramadan Saleh; Taha Abo-Almagd Abdel-Meguid; Murat Gül; Birute Zilaitiene; Edmund Ko; Amarnath Rambhatla; Armand Zini; Kristian Leisegang; Shinnosuke Kuroda; Ralf Henkel; Rossella Cannarella; Ayad Palani; Chak-Lam Cho; Christopher C K Ho; Daniel Suslik Zylbersztejn; Edoardo Pescatori; Eric Chung; Fotios Dimitriadis; Germar-Michael Pinggera; Gian Maria Busetto; Giancarlo Balercia; Gianmaria Salvio; Giovanni M Colpi; Gökhan Çeker; Hisanori Taniguchi; Hussein Kandil; Hyun Jun Park; Israel Maldonado Rosas; Jean de la Rosette; Joao Paulo Greco Cardoso; Jonathan Ramsay; Juan Alvarez; Juan Manuel Corral Molina; Kareim Khalafalla; Kasonde Bowa; Kelton Tremellen; Evangelini Evgeni; Lucia Rocco; Marcelo Gabriel Rodriguez Peña; Marjan Sabbaghian; Marlon Martinez; Mohamed Arafa; Mohamed S Al-Marhoon; Nicholas Tadros; Nicolas Garrido; Osvaldo Rajmil; Pallav Sengupta; Paraskevi Vogiatzi; Parviz Kavoussi; Ponco Birowo; Raghavender Kosgi; Saleem Bani-Hani; Sava Micic; Sijo Parekattil; Sunil Jindal; Tan V Le; Taymour Mostafa; Tuncay Toprak; Yoshiharu Morimoto; Vineet Malhotra; Azin Aghamajidi; Damayanthi Durairajanayagam; Rupin Shah Journal: World J Mens Health Date: 2022-01-01 Impact factor: 6.494