Jodi M Blustin1, Robert D McBane1, Matylda Mazur1, Naser Ammash1, Ondrej Sochor2, Diane E Grill3, Waldemar E Wysokinski4. 1. Division of Cardiovascular Diseases, Gonda Vascular Center, Mayo Clinic, Rochester, MN. 2. Department of Cardiovascular Diseases, International Clinical Research Center, St Anne's University Hospital Brno, Brno, Czech Republic. 3. Department of Health Sciences Research, Mayo Clinic, Rochester, MN. 4. Division of Cardiovascular Diseases, Gonda Vascular Center, Mayo Clinic, Rochester, MN. Electronic address: wysokinski.waldemar@mayo.edu.
Abstract
OBJECTIVE: To determine whether blood type affects the risk of thromboembolic complications in patients with atrial fibrillation (AF). PATIENTS AND METHODS: The Mayo Clinic electronic medical record was searched (between January 1, 2004, and December 31, 2010) to identify all patients with AF with blood group assessment. Records were analyzed for stroke, transient ischemic attack, left atrium appendage thrombus, cerebral or peripheral embolism, and hemorrhagic stroke. All events were adjusted for Congestive heart failure, Hypertension, Age >75 Years, Diabetes mellitus, and Stroke/transient ischemic attack score. RESULTS: Of the 47,816 patients with AF, 14,462 had blood group type available (40% women; mean age, 73±12 years). These included 12,363 patients with nonvalvular atrial fibrillation (NVAF) (40% women; mean age, 73±12 years) and 2099 patients with valvular AF (41% women, mean age, 73±12 years). Within patients with NVAF, the rate of peripheral embolization was significantly lower in those with blood type O (2.0%) than in those with other blood types (3.0%; odds ratio, 0.66; 95% CI, 0.52-0.84; P<.001). Neither cerebral thromboembolic (8.1% for "O" vs 8.2% for "non-O" blood group for NVAF and 7.29% vs 7.76% for valvular AF) nor cerebral hemorrhage (2.0% each group) events rates differed by blood group. CONCLUSION: Blood group O may be protective against peripheral cardioembolic complications of NVAF, which may relate, in part, to reduced circulating von Willebrand factor levels. Cerebral thromboembolic event rates did not differ by blood group.
OBJECTIVE: To determine whether blood type affects the risk of thromboembolic complications in patients with atrial fibrillation (AF). PATIENTS AND METHODS: The Mayo Clinic electronic medical record was searched (between January 1, 2004, and December 31, 2010) to identify all patients with AF with blood group assessment. Records were analyzed for stroke, transient ischemic attack, left atrium appendage thrombus, cerebral or peripheral embolism, and hemorrhagic stroke. All events were adjusted for Congestive heart failure, Hypertension, Age >75 Years, Diabetes mellitus, and Stroke/transient ischemic attack score. RESULTS: Of the 47,816 patients with AF, 14,462 had blood group type available (40% women; mean age, 73±12 years). These included 12,363 patients with nonvalvular atrial fibrillation (NVAF) (40% women; mean age, 73±12 years) and 2099 patients with valvular AF (41% women, mean age, 73±12 years). Within patients with NVAF, the rate of peripheral embolization was significantly lower in those with blood type O (2.0%) than in those with other blood types (3.0%; odds ratio, 0.66; 95% CI, 0.52-0.84; P<.001). Neither cerebral thromboembolic (8.1% for "O" vs 8.2% for "non-O" blood group for NVAF and 7.29% vs 7.76% for valvular AF) nor cerebral hemorrhage (2.0% each group) events rates differed by blood group. CONCLUSION: Blood group O may be protective against peripheral cardioembolic complications of NVAF, which may relate, in part, to reduced circulating von Willebrand factor levels. Cerebral thromboembolic event rates did not differ by blood group.
Authors: Najeebah A Bade; Jamil M Kazma; Richard L Amdur; Julia Ellis-Kahana; Homa K Ahmadzia Journal: J Thromb Thrombolysis Date: 2020-08 Impact factor: 2.300
Authors: Waldemar E Wysokinski; Rowlens M Melduni; Naser M Ammash; Danielle T Vlazny; Ewa Konik; Rayya A Saadiq; Izabela Gosk-Bierska; Joshua Slusser; Diane Grill; Robert D McBane Journal: CJC Open Date: 2020-11-13