Literature DB >> 25658540

IFNL4 ss469415590 polymorphism is associated with unfavourable clinical and immunological status in HIV-infected individuals.

K Machmach1, C Abad-Molina2, M C Romero-Sánchez1, B Dominguez-Molina1, M Moyano3, M M Rodriguez1, M Rafii-El-Idrissi Benhnia4, M E Jimenez-Mejias5, F Vidal6, M A Muñoz-Fernández7, M Genebat5, P Viciana5, M F González-Escribano2, M Leal5, E Ruiz-Mateos8.   

Abstract

The IFNL4 ss469415590 polymorphism, in high linkage disequilibrium with the IL28B rs12979860 variant, has been associated with hepatitis C virus clearance. We evaluated whether ss469415590 is associated with clinical and immunovirological parameters in human immunodeficiency virus-infected subjects. We found an independent association of the IFNL4 ss469415590 polymorphism with higher prevalence of AIDS-defining illnesses and lower CD4 T cell numbers. These results suggest the existence of common host defence mechanisms against different viral infections.
Copyright © 2014 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

Entities:  

Keywords:  AIDS; CD4; HIV infection; IFNL4; IL28B

Mesh：

Substances：

Year:  2014        PMID： 25658540     DOI： 10.1016/j.cmi.2014.10.012

Source DB:  PubMed          Journal:  Clin Microbiol Infect        ISSN： 1198-743X            Impact factor:   8.067


  12 in total

1.  HLA-B*57 and IFNL4-related polymorphisms are associated with protection against HIV-1 disease progression in controllers.

Authors:  B Dominguez-Molina; L Tarancon-Diez; S Hua; C Abad-Molina; E Rodriguez-Gallego; K Machmach; F Vidal; C Tural; S Moreno; J M Goñi; E Ramírez de Arellano; M Del Val; M F Gonzalez-Escribano; J Del Romero; C Rodriguez; L Capa; P Viciana; J Alcamí; X G Yu; B D Walker; Manuel Leal; M Lichterfeld; E Ruiz-Mateos
Journal:  Clin Infect Dis       Date:  2016-12-16       Impact factor: 9.079

2.  Association of IFNλ4 rs12979860 polymorphism with the acquisition of HCV and HIV infections among people who inject drugs.

Authors:  Ene-Ly Jõgeda; Radko Avi; Merit Pauskar; Eveli Kallas; Tõnis Karki; Don Des Jarlais; Anneli Uusküla; Karolin Toompere; Irja Lutsar; Kristi Huik
Journal:  J Med Virol       Date:  2018-08-16       Impact factor: 2.327

3.  IFNL4 Genotype Does Not Associate with CD4 T-Cell Recovery in People Living with Human Immunodeficiency Virus.

Authors:  Eric G Meissner; Dongjun Chung; Betty Tsao; David W Haas; Netanya S Utay
Journal:  AIDS Res Hum Retroviruses       Date:  2020-11-11       Impact factor: 1.723

Review 4.  Interferon Lambda: Modulating Immunity in Infectious Diseases.

Authors:  Mohammedyaseen Syedbasha; Adrian Egli
Journal:  Front Immunol       Date:  2017-02-28       Impact factor: 7.561

Review 5.  Gene-disease association with human IFNL locus polymorphisms extends beyond hepatitis C virus infections.

Authors:  S Chinnaswamy
Journal:  Genes Immun       Date:  2016-06-09       Impact factor: 2.676

Review 6.  Type I interferon and HIV: Subtle balance between antiviral activity, immunopathogenesis and the microbiome.

Authors:  Carolina Scagnolari; Guido Antonelli
Journal:  Cytokine Growth Factor Rev       Date:  2018-03-16       Impact factor: 7.638

7.  Comparative Functional Analysis of 12 Mammalian IFN-λ4 Orthologs.

Authors:  Ashley Paquin; Olusegun O Onabajo; Wei Tang; Ludmila Prokunina-Olsson
Journal:  J Interferon Cytokine Res       Date:  2015-08-26       Impact factor: 2.607

8.  IFN-λ4 inhibits HIV infection of macrophages through signalling of IFN-λR1/IL-10R2 receptor complex.

Authors:  Qi-Jian Su; Xu Wang; Run-Hong Zhou; Le Guo; Hang Liu; Jie-Liang Li; Wen-Zhe Ho
Journal:  Scand J Immunol       Date:  2018-10-10       Impact factor: 3.487

9.  Interferon lambda rs368234815 ΔG/ΔG is associated with higher CD4+:CD8+ T-cell ratio in treated HIV-1 infection.

Authors:  Inês T Freitas; Willard Tinago; Hirofumi Sawa; Julie McAndrews; Brenda Doak; Charlotte Prior-Fuller; Gerard Sheehan; John S Lambert; Eavan Muldoon; Aoife G Cotter; William W Hall; Patrick W G Mallon; Michael J Carr
Journal:  AIDS Res Ther       Date:  2020-04-15       Impact factor: 2.250

10.  Monocytes differentiated into macrophages and dendritic cells in the presence of human IFN-λ3 or IFN-λ4 show distinct phenotypes.

Authors:  Manjarika De; Anand Bhushan; Sreedhar Chinnaswamy
Journal:  J Leukoc Biol       Date:  2020-11-17       Impact factor: 6.011
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