Literature DB >> 25658363

Ascl2 reinforces intestinal stem cell identity.

Kelley S Yan1, Calvin J Kuo2.   

Abstract

Ascl2 is a Wnt-responsive master transcription factor that controls the Lgr5(+) intestinal stem cell gene expression program. Now in Cell Stem Cell, Schuijers et al. (2015) report an Ascl2 positive feedback loop, tuned by previous Wnt pathway activity, that perpetuates intestinal stem cell identity in response to Wnt/R-spondin stimulation.
Copyright © 2015 Elsevier Inc. All rights reserved.

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Year:  2015        PMID： 25658363     DOI： 10.1016/j.stem.2015.01.014

Source DB:  PubMed          Journal:  Cell Stem Cell        ISSN： 1875-9777            Impact factor:   25.269


  9 in total

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Journal:  Transl Lung Cancer Res       Date:  2018-02

2.  Systematic analysis of the achaete-scute complex-like gene signature in clinical cancer patients.

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Authors:  Andre M C Meneses; Kerstin Schneeberger; Hedwig S Kruitwagen; Louis C Penning; Frank G van Steenbeek; Iwan A Burgener; Bart Spee
Journal:  Vet Sci       Date:  2016-10-21

4.  Prolonged Absence of Mechanoluminal Stimulation in Human Intestine Alters the Transcriptome and Intestinal Stem Cell Niche.

Authors:  Minna M Wieck; Christopher R Schlieve; Matthew E Thornton; Kathryn L Fowler; Mubina Isani; Christa N Grant; Ashley E Hilton; Xiaogang Hou; Brendan H Grubbs; Mark R Frey; Tracy C Grikscheit
Journal:  Cell Mol Gastroenterol Hepatol       Date:  2017-01-24

5.  Drosophila intestinal stem and progenitor cells are major sources and regulators of homeostatic niche signals.

Authors:  David P Doupé; Owen J Marshall; Hannah Dayton; Andrea H Brand; Norbert Perrimon
Journal:  Proc Natl Acad Sci U S A       Date:  2018-11-07       Impact factor: 11.205

6.  ASCL2 Maintains Stemness Phenotype through ATG9B and Sensitizes Gliomas to Autophagy Inhibitor.

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Journal:  Adv Sci (Weinh)       Date:  2022-07-26       Impact factor: 17.521

Review 7.  Stem cells: Aging and transcriptional fingerprints.

Authors:  Brice E Keyes; Elaine Fuchs
Journal:  J Cell Biol       Date:  2017-10-25       Impact factor: 10.539

Review 8.  Tales from the crypt: intestinal niche signals in tissue renewal, plasticity and cancer.

Authors:  Maureen Spit; Bon-Kyoung Koo; Madelon M Maurice
Journal:  Open Biol       Date:  2018-09-12       Impact factor: 6.411

9.  Me6TREN targets β-catenin signaling to stimulate intestinal stem cell regeneration after radiation.

Authors:  Sihan Wang; Yi Han; Jing Zhang; Shu Yang; Zeng Fan; Feiling Song; Lijuan He; Wen Yue; Yanhua Li; Xuetao Pei
Journal:  Theranostics       Date:  2020-08-13       Impact factor: 11.556
  9 in total

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