OBJECTIVE: Our aim was to investigate retinal nerve fiber layer (RNFL) thickness in hypertensive patients using spectral-domain optical coherence tomography (SD-OCT) and to evaluate the relationship between RNFL thickness and carotid intima media thickness (CIMT). METHODS: This study included 59 patients with hypertension (HT) (53.6 ± 10.7 years) and 54 age-matched healthy controls (51.0 ± 8.1 years). We evaluated anthropometric and metabolic parameters as well as RNFL and CIMT measurements in patients with hypertension and controls. RESULTS: The average RNFL thickness was 86.60 ± 10.86 μm in hypertensive patients and 93.63 ± 7.30 μm in healthy controls (p < 0.001). Selective thinning of the RNFL was found in the superior and inferior quadrants. Mean CIMT values were higher in patients with HT (0.80 ± 0.15 mm) than the healthy subjects (0.71 ± 0.1 mm) (p < 0.001). The average, inferior and nasal RNFL thickness were negatively associated with diastolic blood pressure respectively (r = - 0.112, r = - 0.210, r = - 0.225). There was an inverse correlation between RNFL thickness in the average and superior retinal quadrant and CIMT (r = - 0.201, r = - 0.185). There were no correlations between RNFL thickness and age, body mass index, fasting plasma glucose, lipid parameters, high-sensitive C-reactive protein and microalbuminuria. CONCLUSION: RNFL thickness is reduced in hypertensive patients and may be associated with atherosclerosis.
OBJECTIVE: Our aim was to investigate retinal nerve fiber layer (RNFL) thickness in hypertensivepatients using spectral-domain optical coherence tomography (SD-OCT) and to evaluate the relationship between RNFL thickness and carotid intima media thickness (CIMT). METHODS: This study included 59 patients with hypertension (HT) (53.6 ± 10.7 years) and 54 age-matched healthy controls (51.0 ± 8.1 years). We evaluated anthropometric and metabolic parameters as well as RNFL and CIMT measurements in patients with hypertension and controls. RESULTS: The average RNFL thickness was 86.60 ± 10.86 μm in hypertensivepatients and 93.63 ± 7.30 μm in healthy controls (p < 0.001). Selective thinning of the RNFL was found in the superior and inferior quadrants. Mean CIMT values were higher in patients with HT (0.80 ± 0.15 mm) than the healthy subjects (0.71 ± 0.1 mm) (p < 0.001). The average, inferior and nasal RNFL thickness were negatively associated with diastolic blood pressure respectively (r = - 0.112, r = - 0.210, r = - 0.225). There was an inverse correlation between RNFL thickness in the average and superior retinal quadrant and CIMT (r = - 0.201, r = - 0.185). There were no correlations between RNFL thickness and age, body mass index, fasting plasma glucose, lipid parameters, high-sensitive C-reactive protein and microalbuminuria. CONCLUSION: RNFL thickness is reduced in hypertensivepatients and may be associated with atherosclerosis.
Entities:
Keywords:
Carotid intima media thickness; hypertension; retinal fiber layer thickness
Authors: Frank C T van der Heide; Indra L M Steens; Anouk F J Geraets; Yuri D Foreman; Ronald M A Henry; Abraham A Kroon; Carla J H van der Kallen; Thomas T van Sloten; Pieter C Dagnelie; Martien C J M van Dongen; Simone J P M Eussen; Tos T J M Berendschot; Jan S A G Schouten; Carroll A B Webers; Marleen M J van Greevenbroek; Anke Wesselius; Annemarie Koster; Nicolaas C Schaper; Miranda T Schram; Seb Köhler; Coen D A Stehouwer Journal: JAMA Netw Open Date: 2021-11-01
Authors: Jun Yong Chow; Poh Fong She; Xu Kent Pee; Wan Norliza Wan Muda; Mae-Lynn Catherine Bastion Journal: PLoS One Date: 2022-04-06 Impact factor: 3.240