| Literature DB >> 25658029 |
Jee Hae Kang1, Minkyung Lee2, Young Hoon Ryu3, Chul Hyoung Lyoo4, Chul Hoon Kim5, Kyo Chul Lee6, Tae Hyun Choi6, Jae Yong Choi7.
Abstract
The aim of this study is to compare [(18)F]FPEB and [(18)F]FDEGPECO for the quantification of mGlu5 receptors in rodent brains. After preparation of radioligands, dynamic PET data was acquired for 90min. Estimated non-displaceable binding potential (BPND) values were calculated from the non-invasive Logan's graphical analysis method. Although both radioligands showed similar radiochemical amenability, [(18)F]FPEB PET showed higher brain uptake and superior binding potential values than those of [(18)F]FDEGPECO PET (peak brain uptakes in the hippocampus and the striatum: 7.2-8.7 vs. 5.0-6.2, BPND: 7.3-9.6 vs. 0.3-0.4 for [(18)F]FPEB and [(18)F]FDEGPECO, respectively). In addition, the target-to-reference ratios for [(18)F]FPEB is >4 fold than those of [(18)F]FDEGPECO. From this evidence, we conclude that [(18)F]FPEB is a superior radioligand for mGlu5 imaging in preclinical studies.Keywords: PET; [(18)F]FDEGPECO; [(18)F]FPEB; mGlu5
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Year: 2015 PMID： 25658029 DOI： 10.1016/j.apradiso.2015.01.025
Source DB: PubMed Journal: Appl Radiat Isot ISSN： 0969-8043 Impact factor: 1.513