Literature DB >> 25656897

Prometastatic NOTCH Signaling in Colon Cancer.

Onno Kranenburg1.   

Abstract

Dysregulation of NOTCH signaling contributes to the development of colorectal cancer, but how this pathway regulates metastasis has so far remained unclear. Sonoshita and colleagues identified a novel NOTCH-driven metastasis pathway that is amenable to therapeutic intervention and generated a companion diagnostic tool that allows analysis of pathway activity in human tumor tissue sections. ©2015 American Association for Cancer Research.

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Year:  2015        PMID： 25656897     DOI： 10.1158/2159-8290.CD-14-1456

Source DB:  PubMed          Journal:  Cancer Discov        ISSN： 2159-8274            Impact factor:   39.397


  7 in total

1.  A novel inhibitor of ADAM17 sensitizes colorectal cancer cells to 5-Fluorouracil by reversing Notch and epithelial-mesenchymal transition in vitro and in vivo.

Authors:  Dan-Dan Li; Chang-Hao Zhao; Huai-Wei Ding; Qiong Wu; Tian-Shu Ren; Jian Wang; Cong-Qin Chen; Qing-Chun Zhao
Journal:  Cell Prolif       Date:  2018-08-02       Impact factor: 6.831

2.  Hes4: A potential prognostic biomarker for newly diagnosed patients with high-grade osteosarcoma.

Authors:  Madonna McManus; Eugenie Kleinerman; Yanwen Yang; John Andrew Livingston; Jared Mortus; Rocio Rivera; Patrick Zweidler-McKay; Keri Schadler
Journal:  Pediatr Blood Cancer       Date:  2016-10-27       Impact factor: 3.167

3.  Cisplatin selects for stem-like cells in osteosarcoma by activating Notch signaling.

Authors:  Ling Yu; Zhengfu Fan; Shuo Fang; Jian Yang; Tian Gao; Bruno M Simões; Rachel Eyre; Weichun Guo; Robert B Clarke
Journal:  Oncotarget       Date:  2016-05-31

4.  Human umbilical vein endothelial cells derived-exosomes promote osteosarcoma cell stemness by activating Notch signaling pathway.

Authors:  Jian Yang; Yong Hu; Lu Wang; Xiangran Sun; Ling Yu; Weichun Guo
Journal:  Bioengineered       Date:  2021-12       Impact factor: 3.269

5.  Targeting ADAM17 inhibits human colorectal adenocarcinoma progression and tumor-initiating cell frequency.

Authors:  Joseph Dosch; Elizabeth Ziemke; Shanshan Wan; Kathryn Luker; Theodore Welling; Karin Hardiman; Eric Fearon; Suneetha Thomas; Matthew Flynn; Jonathan Rios-Doria; Robert Hollingsworth; Ronald Herbst; Elaine Hurt; Judith Sebolt-Leopold
Journal:  Oncotarget       Date:  2017-05-10

Review 6.  Colorectal carcinogenesis: Insights into the cell death and signal transduction pathways: A review.

Authors:  Ashok Kumar Pandurangan; Thomas Divya; Kalaivani Kumar; Vadivel Dineshbabu; Bakthavatchalam Velavan; Ganapasam Sudhandiran
Journal:  World J Gastrointest Oncol       Date:  2018-09-15

Review 7.  Notch signaling pathway: architecture, disease, and therapeutics.

Authors:  Binghan Zhou; Wanling Lin; Yaling Long; Yunkai Yang; Huan Zhang; Kongming Wu; Qian Chu
Journal:  Signal Transduct Target Ther       Date:  2022-03-24
  7 in total

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