Literature DB >> 25656595

Progression-seeking bias and rational optimism in research and development.

Dennis W Lendrem1, B Clare Lendrem1, Richard W Peck2, Stephen C Senn3, Simon Day4, John D Isaacs1.   

Abstract

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Year:  2015        PMID： 25656595     DOI： 10.1038/nrd4320-c1

Source DB:  PubMed          Journal:  Nat Rev Drug Discov        ISSN： 1474-1776            Impact factor:   84.694


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  2 in total

Review 1.  Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders.

Authors:  Katrina J Falkenberg; Ricky W Johnstone
Journal:  Nat Rev Drug Discov       Date:  2014-08-18       Impact factor: 84.694

2.  STAT1 signaling is not regulated by a phosphorylation-acetylation switch.

Authors:  Filipa Antunes; Andreas Marg; Uwe Vinkemeier
Journal:  Mol Cell Biol       Date:  2011-05-16       Impact factor: 4.272
  2 in total
  5 in total

1.  Why is it hard to terminate failing projects in pharmaceutical R&D?

Authors:  Richard W Peck; Dennis W Lendrem; Iain Grant; B Clare Lendrem; John D Isaacs
Journal:  Nat Rev Drug Discov       Date:  2015-08-21       Impact factor: 84.694

2.  Design, Synthesis, Molecular Modeling, and Biological Evaluation of Novel Amine-based Histone Deacetylase Inhibitors.

Authors:  Hazem Abdelkarim; Raghupathi Neelarapu; Antonett Madriaga; Aditya S Vaidya; Irida Kastrati; Bhargava Karumudi; Yue-Ting Wang; Taha Y Taha; Gregory R J Thatcher; Jonna Frasor; Pavel A Petukhov
Journal:  ChemMedChem       Date:  2017-11-30       Impact factor: 3.466

Review 3.  Phase 0/microdosing approaches: time for mainstream application in drug development?

Authors:  Tal Burt; Graeme Young; Wooin Lee; Hiroyuki Kusuhara; Oliver Langer; Malcolm Rowland; Yuichi Sugiyama
Journal:  Nat Rev Drug Discov       Date:  2020-09-08       Impact factor: 84.694

4.  When Quality Beats Quantity: Decision Theory, Drug Discovery, and the Reproducibility Crisis.

Authors:  Jack W Scannell; Jim Bosley
Journal:  PLoS One       Date:  2016-02-10       Impact factor: 3.240

Review 5.  Strategic, feasibility, economic, and cultural aspects of phase 0 approaches: Is it time to change the drug development process in order to increase productivity?

Authors:  Tal Burt; Ad F Roffel; Oliver Langer; Kirsten Anderson; Joseph DiMasi
Journal:  Clin Transl Sci       Date:  2022-04-21       Impact factor: 4.438
  5 in total

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