Fiona E Lecky1, Mahad Omar2, Omar Bouamra1, Tom Jenks1, Antoinette Edwards1, Ceri E Battle3, Phillip A Evans1. 1. The Trauma Audit and Research Network, University of Manchester, Salford, UK. 2. NISCHR Haemostasis Biomedical Research Unit, Morriston Hospital, Swansea, Wales. 3. NISCHR Haemostasis Biomedical Research Unit, Epidemiology Division, Morriston Hospital, Swansea, Wales.
Abstract
OBJECTIVE: To define the relationship between preinjury warfarin use and mortality in a large European sample of trauma patients. METHODS: A multicentred study was conducted using data collated from European (predominately English and Welsh) trauma receiving hospitals. Patient data from the Trauma Audit and Research Network database from 2009 to 2013 were analysed. Univariate and multivariate logistic regression was used to estimate OR for mortality associated with preinjury warfarin use in the whole adult trauma cohort and a matched sample of patients comparable in terms of age, gender, GCS, pre-existing medical conditions and injury severity. RESULTS: A total of 136 617 adult trauma patients (2009-2013) were included, with 499 patients reported to be using warfarin therapy at the time of trauma. Preinjury warfarin use was associated with a significantly higher mortality rate at 30 days postinjury compared with the non-users. Following adjustment of age, injury severity and GCS, preinjury warfarin use was associated with increased mortality in trauma patients (adjusted OR 2.14; 95% CI 1.66 to 2.76; p<0.001). In the matched subset, 22% of warfarinised trauma patients died compared with 16.3% of non-warfarinised trauma patients with comparable age, injury severity and GCS (adjusted OR 1.94; 95% CI 1.25 to 3.01; p=0.003). CONCLUSIONS: Preinjury warfarin use has been demonstrated to be an independent predictor of mortality in trauma patients. Clinicians managing major trauma patients on warfarin need to be aware of the vulnerability of this group. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/
OBJECTIVE: To define the relationship between preinjury warfarin use and mortality in a large European sample of traumapatients. METHODS: A multicentred study was conducted using data collated from European (predominately English and Welsh) trauma receiving hospitals. Patient data from the Trauma Audit and Research Network database from 2009 to 2013 were analysed. Univariate and multivariate logistic regression was used to estimate OR for mortality associated with preinjury warfarin use in the whole adult trauma cohort and a matched sample of patients comparable in terms of age, gender, GCS, pre-existing medical conditions and injury severity. RESULTS: A total of 136 617 adult traumapatients (2009-2013) were included, with 499 patients reported to be using warfarin therapy at the time of trauma. Preinjury warfarin use was associated with a significantly higher mortality rate at 30 days postinjury compared with the non-users. Following adjustment of age, injury severity and GCS, preinjury warfarin use was associated with increased mortality in traumapatients (adjusted OR 2.14; 95% CI 1.66 to 2.76; p<0.001). In the matched subset, 22% of warfarinised traumapatients died compared with 16.3% of non-warfarinised traumapatients with comparable age, injury severity and GCS (adjusted OR 1.94; 95% CI 1.25 to 3.01; p=0.003). CONCLUSIONS: Preinjury warfarin use has been demonstrated to be an independent predictor of mortality in traumapatients. Clinicians managing major traumapatients on warfarin need to be aware of the vulnerability of this group. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/
Authors: Felix M Bläsius; Markus Laubach; Hagen Andruszkow; Cavan Lübke; Philipp Lichte; Rolf Lefering; Frank Hildebrand; Klemens Horst Journal: Sci Rep Date: 2021-07-26 Impact factor: 4.379