Mona Choudhary1, Arvind Kumar1, Madhavi Tripathi2, Triptish Bhatia1, Venkataram Shivakumar3, Ram Pratap Beniwal1, Ruben C Gur4, Raquel E Gur4, Vishwajit L Nimgaonkar5, Smita N Deshpande6. 1. Post Graduate Institute of Medical Education and Research Dr. Ram Manohar Lohia Hospital (PGIMER-RMLH), Park Street, New Delhi, India. 2. Institute of Nuclear Medicine and Allied Sciences, Timarpur, New Delhi, India. 3. Translational Psychiatry Laboratory, Cognitive Neurobiology Division, Neurobiology Research Center, National Institute of Mental Health and Neuro Science, Bangaluru, India. 4. Schizophrenia Research Centre, Neuropsychiatry Section, Department of Psychiatry, The University of Pennsylvania, Philadelphia, PA, USA. 5. Department of Psychiatry, University of Pittsburgh, Pittsburgh, USA; Department of Human Genetics, University of Pittsburgh, Pittsburgh, USA. 6. Post Graduate Institute of Medical Education and Research Dr. Ram Manohar Lohia Hospital (PGIMER-RMLH), Park Street, New Delhi, India. Electronic address: indusszgenes@gmail.com.
Abstract
BACKGROUND: Schizophrenia cases have been consistently shown to have behavioural and neurofunctional abnormalities but studies during early course are scarce. The present work assesses the performance of acute first episode schizophrenia cases on correlation of a facial emotion perception task with brain function using fluorine-18 fluorodeoxyglucose (FDG) positron emission tomography (PET). METHODS: Twenty First episode schizophrenia cases and 20 matched healthy controls living in the community were enrolled. For cases, longest duration of illness was one year and treatment with neuroleptic did not exceed two weeks on the day of scan. To measure facial emotion perception (FEP) both groups were administered the Emotion battery from the Penn Computerized Battery followed by PET acquisition. SPM 8 analysis for group differences at p<0.001 was performed. RESULTS: Schizophrenia subjects showed hypoactivation of bilateral prefrontal cortices and fusiform gyrii, with significant hyperactivation of bilateral basal ganglia and left precuneus. Positive correlation of metabolism in prefrontal cortex and performance indices on emotions domain was seen. No correlation of chlorpromazine equivalent days with metabolism in basal ganglia was observed. CONCLUSIONS: The performance of schizophrenia cases on FEP task was significantly impaired in comparison to the control group. Brain regions implicated in emotion processing showed hypometabolism in cases as compared to controls. Failure of schizophrenia cases to optimally recruit brain circuitry may be contributing to deficits on FEP task. These findings suggest inherent deficits in neural circuitry of emotion processing in schizophrenia; devoid of confounding effects of neuroleptics and duration of illness.
BACKGROUND:Schizophrenia cases have been consistently shown to have behavioural and neurofunctional abnormalities but studies during early course are scarce. The present work assesses the performance of acute first episode schizophrenia cases on correlation of a facial emotion perception task with brain function using fluorine-18 fluorodeoxyglucose (FDG) positron emission tomography (PET). METHODS: Twenty First episode schizophrenia cases and 20 matched healthy controls living in the community were enrolled. For cases, longest duration of illness was one year and treatment with neuroleptic did not exceed two weeks on the day of scan. To measure facial emotion perception (FEP) both groups were administered the Emotion battery from the Penn Computerized Battery followed by PET acquisition. SPM 8 analysis for group differences at p<0.001 was performed. RESULTS:Schizophrenia subjects showed hypoactivation of bilateral prefrontal cortices and fusiform gyrii, with significant hyperactivation of bilateral basal ganglia and left precuneus. Positive correlation of metabolism in prefrontal cortex and performance indices on emotions domain was seen. No correlation of chlorpromazine equivalent days with metabolism in basal ganglia was observed. CONCLUSIONS: The performance of schizophrenia cases on FEP task was significantly impaired in comparison to the control group. Brain regions implicated in emotion processing showed hypometabolism in cases as compared to controls. Failure of schizophrenia cases to optimally recruit brain circuitry may be contributing to deficits on FEP task. These findings suggest inherent deficits in neural circuitry of emotion processing in schizophrenia; devoid of confounding effects of neuroleptics and duration of illness.
Authors: L E DeLisi; H H Holcomb; R M Cohen; D Pickar; W Carpenter; J M Morihisa; A C King; R Kessler; M S Buchsbaum Journal: J Cereb Blood Flow Metab Date: 1985-06 Impact factor: 6.200
Authors: Keith H Nuechterlein; Deanna M Barch; James M Gold; Terry E Goldberg; Michael F Green; Robert K Heaton Journal: Schizophr Res Date: 2004-12-15 Impact factor: 4.939
Authors: Martina Reske; Thilo Kellermann; Ute Habel; N Jon Shah; Volker Backes; Martina von Wilmsdorff; Tony Stöcker; Wolfgang Gaebel; Frank Schneider Journal: J Psychiatr Res Date: 2007-04-27 Impact factor: 4.791
Authors: Michael F Green; Pamela D Butler; Yue Chen; Mark A Geyer; Steven Silverstein; Jonathan K Wynn; Jong H Yoon; Vance Zemon Journal: Schizophr Bull Date: 2008-11-20 Impact factor: 9.306
Authors: Richard Newton; Alice Rouleau; Anna-Greta Nylander; Jean-Yves Loze; Henrike K Resemann; Sara Steeves; Benedicto Crespo-Facorro Journal: NPJ Schizophr Date: 2018-10-15
Authors: Jeong Ha Park; Ji Son Hong; Sun Mi Kim; Kyung Joon Min; Un Sun Chung; Doug Hyun Han Journal: Clin Psychopharmacol Neurosci Date: 2019-05-31 Impact factor: 2.582