| Literature DB >> 25655718 |
Li-Ying Ma1, Bo Wang1, Lu-Ping Pang1, Miao Zhang1, Sai-Qi Wang1, Yi-Chao Zheng1, Kun-Peng Shao1, Deng-Qi Xue1, Hong-Min Liu2.
Abstract
A series of novel 1,2,3-triazole-pyrimidine-urea hybrids were designed, synthesized and evaluated for anticancer activity against four selected cancer cell lines (MGC-803, EC-109, MCF-7 and B16-F10). Majority of the synthesized compounds exhibited moderate to potent activity against all the cancer cell lines assayed. Particularly, compounds 26, 30 and 38 exhibited excellent growth inhibition against B16-F10 with IC50 values of 32nM, 35nM and 42nM, respectively. Flow cytometry analysis demonstrated that compound 26 induced the cellular apoptosis in a concentration-dependent manner.Entities:
Keywords: Anticancer; Apoptosis; Pyrimidine; Triazole; Urea
Mesh：
Substances：
Year: 2015 PMID： 25655718 DOI： 10.1016/j.bmcl.2014.12.087
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823