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Literature DB >> 25655439

Th17 cytokines in non-melanoma skin cancer.

Abstract

T-helper-type 17 cytokines have been implicated in epithelial cancer progression at mucosal sites. In this issue of the European Journal of Immunology, Nardinocchi et al. [Eur. J. Immunol. 2015. 45: 922-931] show that the Th17 cytokines IL-17 and IL-22 can both signal to nonmelanoma skin cancer cells, inducing both cellular proliferation and enhanced migration of human basal cell carcinoma and squamous cell carcinoma cell lines in vitro. These cytokines were also shown to exacerbate tumor growth in mice injected with the squamous cell carcinoma line, CAL27. Thus, IL-17 and IL-22 may be key factors in skin cancer progression and may provide novel prognostic markers in nonmelanoma skin cancer.

Entities: CellLine Disease Gene Mutation Species

Keywords: Cancer; IL-17; IL-22; Skin; T cells

Mesh：

Substances：

Year: 2015 PMID： 25655439 PMCID： PMC4461870 DOI： 10.1002/eji.201545456

Source DB: PubMed Journal: Eur J Immunol ISSN： 0014-2980 Impact factor: 5.532

22 in total

1. IL-17F deficiency inhibits small intestinal tumorigenesis in ApcMin/+ mice.

Authors: Wook-Jin Chae; Alfred L M Bothwell
Journal: Biochem Biophys Res Commun Date: 2011-09-12 Impact factor: 3.575

Review 2. TH17 cells in development: an updated view of their molecular identity and genetic programming.

Authors: Chen Dong
Journal: Nat Rev Immunol Date: 2008-05 Impact factor: 53.106

Review 3. Th17 cell differentiation: the long and winding road.

Authors: Mandy J McGeachy; Daniel J Cua
Journal: Immunity Date: 2008-04 Impact factor: 31.745

4. STAT3 regulates cytokine-mediated generation of inflammatory helper T cells.

Authors: Xuexian O Yang; Athanasia D Panopoulos; Roza Nurieva; Seon Hee Chang; Demin Wang; Stephanie S Watowich; Chen Dong
Journal: J Biol Chem Date: 2007-02-03 Impact factor: 5.157

5. Interleukin-17 receptor a signaling in transformed enterocytes promotes early colorectal tumorigenesis.

Authors: Kepeng Wang; Min Kyoung Kim; Giuseppe Di Caro; Jerry Wong; Shabnam Shalapour; Jun Wan; Wei Zhang; Zhenyu Zhong; Elsa Sanchez-Lopez; Li-Wha Wu; Koji Taniguchi; Ying Feng; Eric Fearon; Sergei I Grivennikov; Michael Karin
Journal: Immunity Date: 2014-11-25 Impact factor: 31.745

6. Interleukin-17 and interleukin-22 promote tumor progression in human nonmelanoma skin cancer.

Authors: Lavinia Nardinocchi; Giulio Sonego; Francesca Passarelli; Simona Avitabile; Claudia Scarponi; Cristina Maria Failla; Stefano Simoni; Cristina Albanesi; Andrea Cavani
Journal: Eur J Immunol Date: 2015-01-16 Impact factor: 5.532

7. Enrichment of regulatory T cells in invasive breast tumor correlates with the upregulation of IL-17A expression and invasiveness of the tumor.

Authors: Luciana Benevides; Cristina R B Cardoso; Daniel G Tiezzi; Heitor R C Marana; Jurandyr M Andrade; João S Silva
Journal: Eur J Immunol Date: 2013-05-16 Impact factor: 5.532

4. Practical recommendations for systemic treatment in psoriasis in case of coexisting inflammatory, neurologic, infectious or malignant disorders (BETA-PSO: Belgian Evidence-based Treatment Advice in Psoriasis; part 2).

Authors: J L W Lambert; S Segaert; P D Ghislain; T Hillary; A Nikkels; F Willaert; J Lambert; R Speeckaert
Journal: J Eur Acad Dermatol Venereol Date: 2020-08-13 Impact factor: 6.166

4 in total

Th17 cytokines in non-melanoma skin cancer.

1. IL-17F deficiency inhibits small intestinal tumorigenesis in ApcMin/+ mice.

Review 2. TH17 cells in development: an updated view of their molecular identity and genetic programming.

Review 3. Th17 cell differentiation: the long and winding road.

4. STAT3 regulates cytokine-mediated generation of inflammatory helper T cells.

5. Interleukin-17 receptor a signaling in transformed enterocytes promotes early colorectal tumorigenesis.

6. Interleukin-17 and interleukin-22 promote tumor progression in human nonmelanoma skin cancer.

7. Enrichment of regulatory T cells in invasive breast tumor correlates with the upregulation of IL-17A expression and invasiveness of the tumor.

Review 8. Non-melanoma skin cancer: carcinogenesis and chemoprevention.

9. IL-23 promotes maintenance but not commitment to the Th17 lineage.

Review 10. Th17 cells in cancer: the ultimate identity crisis.

Review 1. Targeting the Tumor Microenvironment: The Protumor Effects of IL-17 Related to Cancer Type.

2. IL-17A promotes the invasion-metastasis cascade via the AKT pathway in hepatocellular carcinoma.

Review 3. The Human Microbiota and Skin Cancer.

4. Practical recommendations for systemic treatment in psoriasis in case of coexisting inflammatory, neurologic, infectious or malignant disorders (BETA-PSO: Belgian Evidence-based Treatment Advice in Psoriasis; part 2).