Literature DB >> 25654547

mTOR: a pharmacologic target for autophagy regulation.

Young Chul Kim, Kun-Liang Guan.   

Abstract

mTOR, a serine/threonine kinase, is a master regulator of cellular metabolism. mTOR regulates cell growth and proliferation in response to a wide range of cues, and its signaling pathway is deregulated in many human diseases. mTOR also plays a crucial role in regulating autophagy. This Review provides an overview of the mTOR signaling pathway, the mechanisms of mTOR in autophagy regulation, and the clinical implications of mTOR inhibitors in disease treatment.

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Year:  2015        PMID： 25654547      PMCID： PMC4382265          DOI： 10.1172/JCI73939

Source DB:  PubMed          Journal:  J Clin Invest        ISSN： 0021-9738            Impact factor:   14.808


  119 in total

1.  Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling.

Authors:  Ken Inoki; Yong Li; Tian Xu; Kun-Liang Guan
Journal:  Genes Dev       Date:  2003-07-17       Impact factor: 11.361

2.  Role and regulation of starvation-induced autophagy in the Drosophila fat body.

Authors:  Ryan C Scott; Oren Schuldiner; Thomas P Neufeld
Journal:  Dev Cell       Date:  2004-08       Impact factor: 12.270

Review 3.  Functions of lysosomes.

Authors:  C De Duve; R Wattiaux
Journal:  Annu Rev Physiol       Date:  1966       Impact factor: 19.318

4.  TSC2 mediates cellular energy response to control cell growth and survival.

Authors:  Ken Inoki; Tianqing Zhu; Kun-Liang Guan
Journal:  Cell       Date:  2003-11-26       Impact factor: 41.582

5.  Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease.

Authors:  Brinda Ravikumar; Coralie Vacher; Zdenek Berger; Janet E Davies; Shouqing Luo; Lourdes G Oroz; Francesco Scaravilli; Douglas F Easton; Rainer Duden; Cahir J O'Kane; David C Rubinsztein
Journal:  Nat Genet       Date:  2004-05-16       Impact factor: 38.330

6.  Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton.

Authors:  D D Sarbassov; Siraj M Ali; Do-Hyung Kim; David A Guertin; Robert R Latek; Hediye Erdjument-Bromage; Paul Tempst; David M Sabatini
Journal:  Curr Biol       Date:  2004-07-27       Impact factor: 10.834

7.  Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase.

Authors:  Philippe P Roux; Bryan A Ballif; Rana Anjum; Steven P Gygi; John Blenis
Journal:  Proc Natl Acad Sci U S A       Date:  2004-09-01       Impact factor: 11.205

8.  Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity.

Authors:  Sung Hee Um; Francesca Frigerio; Mitsuhiro Watanabe; Frédéric Picard; Manel Joaquin; Melanie Sticker; Stefano Fumagalli; Peter R Allegrini; Sara C Kozma; Johan Auwerx; George Thomas
Journal:  Nature       Date:  2004-08-11       Impact factor: 49.962

9.  The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins.

Authors:  Laura S Harrington; Greg M Findlay; Alex Gray; Tatiana Tolkacheva; Simon Wigfield; Heike Rebholz; Jill Barnett; Nick R Leslie; Susan Cheng; Peter R Shepherd; Ivan Gout; C Peter Downes; Richard F Lamb
Journal:  J Cell Biol       Date:  2004-07-12       Impact factor: 10.539

10.  Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb.

Authors:  Andrew R Tee; Brendan D Manning; Philippe P Roux; Lewis C Cantley; John Blenis
Journal:  Curr Biol       Date:  2003-08-05       Impact factor: 10.834
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  520 in total

1.  Rapamycin Prolongs Graft Survival and Induces CD4+IFN-γ+IL-10+ Regulatory Type 1 Cells in Old Recipient Mice.

Authors:  Markus Quante; Timm Heinbokel; Karoline Edtinger; Koichiro Minami; Hirofumi Uehara; Yeqi Nian; Haruhito Azuma; Reza Abdi; Abdallah Elkhal; Stefan G Tullius
Journal:  Transplantation       Date:  2018-01       Impact factor: 4.939

Review 2.  Regulation of mitophagy in ischemic brain injury.

Authors:  Yang Yuan; Xiangnan Zhang; Yanrong Zheng; Zhong Chen
Journal:  Neurosci Bull       Date:  2015-07-28       Impact factor: 5.203

Review 3.  mTOR function and therapeutic targeting in breast cancer.

Authors:  Stephen H Hare; Amanda J Harvey
Journal:  Am J Cancer Res       Date:  2017-03-01       Impact factor: 6.166

Review 4.  Metformin, the aspirin of the 21st century: its role in gestational diabetes mellitus, prevention of preeclampsia and cancer, and the promotion of longevity.

Authors:  Roberto Romero; Offer Erez; Maik Hüttemann; Eli Maymon; Bogdan Panaitescu; Agustin Conde-Agudelo; Percy Pacora; Bo Hyun Yoon; Lawrence I Grossman
Journal:  Am J Obstet Gynecol       Date:  2017-06-12       Impact factor: 8.661

5.  Activation of DRD5 (dopamine receptor D5) inhibits tumor growth by autophagic cell death.

Authors:  Zhi Gen Leng; Shao Jian Lin; Ze Rui Wu; Yu Hang Guo; Lin Cai; Han Bing Shang; Hao Tang; Ya Jun Xue; Mei Qing Lou; Wenxiu Zhao; Wei-Dong Le; Wei Guo Zhao; Xun Zhang; Zhe Bao Wu
Journal:  Autophagy       Date:  2017-06-14       Impact factor: 16.016

6.  Suppression of Sestrins in aging and osteoarthritic cartilage: dysfunction of an important stress defense mechanism.

Authors:  T Shen; O Alvarez-Garcia; Y Li; M Olmer; M K Lotz
Journal:  Osteoarthritis Cartilage       Date:  2016-09-29       Impact factor: 6.576

7.  Expression, modulation, and clinical correlates of the autophagy protein Beclin-1 in esophageal adenocarcinoma.

Authors:  Katherine M Weh; Amy B Howell; Laura A Kresty
Journal:  Mol Carcinog       Date:  2015-11-19       Impact factor: 4.784

8.  Triptolide induces autophagy and apoptosis through ERK activation in human breast cancer MCF-7 cells.

Authors:  Huan Gao; Yue Zhang; Lei Dong; Xiao-Yu Qu; Li-Na Tao; Yue-Ming Zhang; Jing-Hui Zhai; Yan-Qing Song
Journal:  Exp Ther Med       Date:  2018-02-01       Impact factor: 2.447

9.  A fine-tuning mechanism underlying self-control for autophagy: deSUMOylation of BECN1 by SENP3.

Authors:  Kejia Liu; Chu Guo; Yimin Lao; Jie Yang; Fei Chen; Yuzheng Zhao; Yi Yang; Jie Yang; Jing Yi
Journal:  Autophagy       Date:  2019-08-02       Impact factor: 16.016

10.  Sucrose, But Not Glucose, Blocks IL1-β-Induced Inflammatory Response in Human Chondrocytes by Inducing Autophagy via AKT/mTOR Pathway.

Authors:  Nazir M Khan; Mohammad Y Ansari; Tariq M Haqqi
Journal:  J Cell Biochem       Date:  2016-10-12       Impact factor: 4.429
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