Literature DB >> 2565419

Predisposition to familial osteoarthrosis linked to type II collagen gene.

A Palotie1, P Väisänen, J Ott, L Ryhänen, K Elima, M Vikkula, K Cheah, E Vuorio, L Peltonen.   

Abstract

The genetic background of two families, in whom a predisposition to primary osteoarthrosis is inherited as a dominant trait, was investigated. Use of restriction fragment length polymorphisms within and around the type II collagen gene on chromosome 12 revealed a linkage between this cartilage-specific gene and primary osteoarthrosis.

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Year:  1989        PMID: 2565419     DOI: 10.1016/s0140-6736(89)92507-5

Source DB:  PubMed          Journal:  Lancet        ISSN: 0140-6736            Impact factor:   79.321


  39 in total

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Review 8.  Osteoarthritis in the aged. Epidemiological issues and optimal management.

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9.  Kniest dysplasia is caused by dominant collagen II (COL2A1) mutations: parental somatic mosaicism manifesting as Stickler phenotype and mild spondyloepiphyseal dysplasia.

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