Literature DB >> 25653433

Analysis by live imaging of effects of the adenovirus E4orf4 protein on passage through mitosis of H1299 tumor cells.

Neera Sriskandarajah1, Paola Blanchette2, Thomas J Kucharski1, Jose G Teodoro1, Philip E Branton3.   

Abstract

The adenovirus E4orf4 protein expressed at high levels kills cancer cells but not normal human primary cells. Previous studies suggested that disruption of processes that regulate mitosis may underlie E4orf4 toxicity. Here we have used live imaging to show that E4orf4 induces a slowed defective transit through mitosis, exhibiting a delay or often failure in cytokinesis that may account for an accumulation of G1 tetraploids in the population of dying E4orf4-expressing cells.
Copyright © 2015, American Society for Microbiology. All Rights Reserved.

Entities:  

Mesh：

Substances：

Year:  2015        PMID： 25653433      PMCID： PMC4442376          DOI： 10.1128/JVI.03437-14

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  37 in total

1.  Adenovirus E4orf4 protein reduces phosphorylation of c-Fos and E1A proteins while simultaneously reducing the level of AP-1.

Authors:  U Müller; T Kleinberger; T Shenk
Journal:  J Virol       Date:  1992-10       Impact factor: 5.103

2.  Adenovirus E4 open reading frame 4 protein autoregulates E4 transcription by inhibiting E1A transactivation of the E4 promoter.

Authors:  M Bondesson; K Ohman; M Manervik; S Fan; G Akusjärvi
Journal:  J Virol       Date:  1996-06       Impact factor: 5.103

3.  Adenovirus type 5 E4 open reading frame 4 protein induces apoptosis in transformed cells.

Authors:  R Shtrichman; T Kleinberger
Journal:  J Virol       Date:  1998-04       Impact factor: 5.103

4.  Regulation of adenovirus alternative RNA splicing by dephosphorylation of SR proteins.

Authors:  A Kanopka; O Mühlemann; S Petersen-Mahrt; C Estmer; C Ohrmalm; G Akusjärvi
Journal:  Nature       Date:  1998-05-14       Impact factor: 49.962

5.  Adenovirus E4 open reading frame 4-induced dephosphorylation inhibits E1A activation of the E2 promoter and E2F-1-mediated transactivation independently of the retinoblastoma tumor suppressor protein.

Authors:  M Mannervik; S Fan; A C Ström; K Helin; G Akusjärvi
Journal:  Virology       Date:  1999-04-10       Impact factor: 3.616

6.  Adenovirus type 5 early region 4 is responsible for E1A-induced p53-independent apoptosis.

Authors:  R C Marcellus; J G Teodoro; T Wu; D E Brough; G Ketner; G C Shore; P E Branton
Journal:  J Virol       Date:  1996-09       Impact factor: 5.103

7.  Induction of apoptosis by adenovirus E4orf4 protein is specific to transformed cells and requires an interaction with protein phosphatase 2A.

Authors:  R Shtrichman; R Sharf; H Barr; T Dobner; T Kleinberger
Journal:  Proc Natl Acad Sci U S A       Date:  1999-08-31       Impact factor: 11.205

8.  The 55 kd regulatory subunit of Drosophila protein phosphatase 2A is required for anaphase.

Authors:  R E Mayer-Jaekel; H Ohkura; R Gomes; C E Sunkel; S Baumgartner; B A Hemmings; D M Glover
Journal:  Cell       Date:  1993-02-26       Impact factor: 41.582

9.  Drosophila mutants in the 55 kDa regulatory subunit of protein phosphatase 2A show strongly reduced ability to dephosphorylate substrates of p34cdc2.

Authors:  R E Mayer-Jaekel; H Ohkura; P Ferrigno; N Andjelkovic; K Shiomi; T Uemura; D M Glover; B A Hemmings
Journal:  J Cell Sci       Date:  1994-09       Impact factor: 5.285

10.  The early region 4 orf4 protein of human adenovirus type 5 induces p53-independent cell death by apoptosis.

Authors:  R C Marcellus; J N Lavoie; D Boivin; G C Shore; G Ketner; P E Branton
Journal:  J Virol       Date:  1998-09       Impact factor: 5.103
View more
  3 in total

1.  An Interaction with PARP-1 and Inhibition of Parylation Contribute to Attenuation of DNA Damage Signaling by the Adenovirus E4orf4 Protein.

Authors:  Keren Nebenzahl-Sharon; Rakefet Sharf; Jana Amer; Hassan Shalata; Hanan Khoury-Haddad; Sook-Young Sohn; Nabieh Ayoub; Patrick Hearing; Tamar Kleinberger
Journal:  J Virol       Date:  2019-09-12       Impact factor: 5.103

2.  The Human Adenovirus Type 5 E4orf4 Protein Targets Two Phosphatase Regulators of the Hippo Signaling Pathway.

Authors:  Melissa Z Mui; Yiwang Zhou; Paola Blanchette; Naila Chughtai; Jennifer F Knight; Tina Gruosso; Andreas I Papadakis; Sidong Huang; Morag Park; Anne-Claude Gingras; Philip E Branton
Journal:  J Virol       Date:  2015-06-17       Impact factor: 5.103

Review 3.  Mechanisms of cancer cell killing by the adenovirus E4orf4 protein.

Authors:  Tamar Kleinberger
Journal:  Viruses       Date:  2015-05-07       Impact factor: 5.048
  3 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.