Afif EL-Khuffash1, Adam T James2, Aoife Cleary2, Jana Semberova3, Orla Franklin4, Jan Miletin5. 1. Department of Neonatology, The Rotunda Hospital, Dublin, Ireland School of Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland. 2. Department of Neonatology, The Rotunda Hospital, Dublin, Ireland. 3. Coombe Women and Infants University Hospital, Dublin, Ireland Institute for the Care of Mother and Child, Prague, Czech Republic. 4. The Department of Paediatric Cardiology, Our Lady's Children's Hospital Crumlin, Dublin, Ireland. 5. Coombe Women and Infants University Hospital, Dublin, Ireland Institute for the Care of Mother and Child, Prague, Czech Republic UCD School of Medicine and Medical Sciences, Dublin, Ireland.
Abstract
OBJECTIVE: To investigate the effect of late treatment with intravenous paracetamol on patent ductus arteriosus (PDA) closure prior to possible PDA ligation. METHODS: A retrospective review of infants with a haemodynamically significant PDA, considered for PDA ligation and treated with intravenous paracetamol prior to possible ligation. RESULTS: Thirty six infants with a median gestation of 26.1 weeks received paracetamol at a median age of 27 days. Paracetamol was associated with immediate closure in nine (25%) infants. There was no response to paracetamol treatment in four (11%) infants who subsequently underwent a PDA ligation. In 23 (64%) infants, the PDA constricted and all but one of this group demonstrated complete PDA closure prior to discharge. CONCLUSIONS: There may be a role for intravenous paracetamol in late closure of infants with a significant PDA to avoid ligation. The use of paracetamol for late treatment of PDA should be systematically evaluated. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.
OBJECTIVE: To investigate the effect of late treatment with intravenous paracetamol on patent ductus arteriosus (PDA) closure prior to possible PDA ligation. METHODS: A retrospective review of infants with a haemodynamically significant PDA, considered for PDA ligation and treated with intravenous paracetamol prior to possible ligation. RESULTS: Thirty six infants with a median gestation of 26.1 weeks received paracetamol at a median age of 27 days. Paracetamol was associated with immediate closure in nine (25%) infants. There was no response to paracetamol treatment in four (11%) infants who subsequently underwent a PDA ligation. In 23 (64%) infants, the PDA constricted and all but one of this group demonstrated complete PDA closure prior to discharge. CONCLUSIONS: There may be a role for intravenous paracetamol in late closure of infants with a significant PDA to avoid ligation. The use of paracetamol for late treatment of PDA should be systematically evaluated. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.
Entities:
Keywords:
PDA; Paracetamol; late treatment; ligation; preterm infants
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