Shin Okamoto1, Osamu Iida2, Masato Nakamura3, Yasutaka Yamauchi4, Masashi Fukunaga5, Yoshiaki Yokoi6, Yoshimitsu Soga7, Kan Zen8, Keisuke Hirano9, Nobuhiro Suematsu10, Kenji Suzuki11, Yoshiaki Shintani12, Yusuke Miyashita13, Kazushi Urasawa14, Ikuro Kitano15, Terutoshi Yamaoka16, Norihiko Ohura17, Toshimitsu Hamasaki18, Masaaki Uematsu2, Shinsuke Nanto19. 1. Cardiovascular Center, Kansai Rosai Hospital, Hyogo, Japan shiinn.okmt@gmail.com. 2. Cardiovascular Center, Kansai Rosai Hospital, Hyogo, Japan. 3. Division of Cardiovascular Medicine, Toho University, Ohashi Medical Center, Tokyo, Japan. 4. Cardiovascular Center, Kikuna Memorial Hospital, Kanagawa, Japan. 5. Cardiovascular Division, Department of Internal Medicine, Hyogo College of Medicine, Hyogo, Japan. 6. Department of Cardiology, Kishiwada Tokushukai Hospital, Osaka, Japan. 7. Department of Cardiology, Kokura Memorial Hospital, Fukuoka, Japan. 8. Department of Cardiovascular Medicine, Omihachiman Community Medical Center, Shiga, Japan. 9. Division of Cardiology, Saiseikai Yokohama-City Eastern Hospital, Kanagawa, Japan. 10. Department of Cardiology, Fukuoka Red Cross Hospital, Fukuoka, Japan. 11. Department of Cardiology, Sendai Kousei Hospital, Miyagi, Japan. 12. Department of Cardiology, Shin-Koga Hospital, Fukuoka, Japan. 13. Department of Cardiovascular Medicine, Shinshu University Graduate School of Medicine, Nagano, Japan. 14. Cardiovascular Center, Tokeidai Memorial Hospital, Hokkaido, Japan. 15. Wound Treatment Center, Shin-suma General Hospital, Hyogo, Japan. 16. Department of Vascular Surgery, Matsuyama Red Cross Hospital, Ehime, Japan. 17. Department of Plastic and Reconstructive Surgery, Kyorin University School of Medicine, Tokyo, Japan. 18. Department of Biomedical Statistics, Osaka University Graduate School of Medicine, Osaka, Japan. 19. Department of Advanced Cardiovascular Therapeutics, Osaka University Graduate School of Medicine, Osaka, Japan.
Abstract
BACKGROUND: Although skin perfusion pressure (SPP) is widely used clinically to predict probability of wound healing, correlation between clinical outcomes and SPP has not been systematically studied. METHODS: This subanalysis of the prospective multicenter OLIVE registry of patients who received infrainguinal endovascular therapy (EVT) for critical limb ischemia (CLI) assessed the association between clinical outcomes and postoperative SPP in 211 consecutive patients. Logistic regression analysis was performed, with amputation-free survival (AFS), modified major adverse limb events (MALEs), and complete wound healing as dependent variables and postprocedural SPP as independent variable. RESULT: Pre- and postprocedural SPP was 28 ± 11 and 46 ± 18 mm Hg, respectively. In logistic regression analysis, postprocedural SPP correlated with 1-year AFS (P = .018), modified MALEs (P < .001), and wound healing (P = .022). CONCLUSION: Postprocedural SPP correlates with clinical outcomes after EVT for patients with CLI.
BACKGROUND: Although skin perfusion pressure (SPP) is widely used clinically to predict probability of wound healing, correlation between clinical outcomes and SPP has not been systematically studied. METHODS: This subanalysis of the prospective multicenter OLIVE registry of patients who received infrainguinal endovascular therapy (EVT) for critical limb ischemia (CLI) assessed the association between clinical outcomes and postoperative SPP in 211 consecutive patients. Logistic regression analysis was performed, with amputation-free survival (AFS), modified major adverse limb events (MALEs), and complete wound healing as dependent variables and postprocedural SPP as independent variable. RESULT: Pre- and postprocedural SPP was 28 ± 11 and 46 ± 18 mm Hg, respectively. In logistic regression analysis, postprocedural SPP correlated with 1-year AFS (P = .018), modified MALEs (P < .001), and wound healing (P = .022). CONCLUSION: Postprocedural SPP correlates with clinical outcomes after EVT for patients with CLI.
Authors: Sanne M Schreuder; Yvette M G A Hendrix; Jim A Reekers; Shandra Bipat Journal: Cardiovasc Intervent Radiol Date: 2017-09-18 Impact factor: 2.740