Jincheng Zeng1, Bin Kong2, Wenyu Xiang2, Yuchi Gao2, Yuanbin Lu2, Wandang Wang2, Junai Zhang2, Dongzi Lin3, Ganbin Liu3, Junfa Xu1. 1. Institute of Laboratory Medicine, Guangdong Medical College, Dongguan 523808; Guangdong Provincial Key Laboratory for Medical Molecular Diagnostics, Dongguan 523808, China. 2. Institute of Laboratory Medicine, Guangdong Medical College, Dongguan 523808, China. 3. Dongguang Hospital for Chronic Diseases, Dongguan 523000, China.
Abstract
OBJECTIVE: To investigate the role of serum soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) in patients with active pulmonary tuberculosis (ATB) and explore its clinical significance. METHODS: The study included 78 cases of ATB patients and 40 cases of healthy volunteers from Dongguan Hospital for Chronic Diseases. Peripheral blood neutrophils and monocytes were counted by automated hematology analyzer. Serum sTREM-1 levels were detected by ELISA, and then the relevance with neutrophils and monocytes were analyzed by Pearson correlation test, respectively. RESULTS: The absolute numbers of neutrophils and monocytes, and the levels of serum sTREM-1 were higher in ATB patients than those in normal controls. In smear positive patients, the absolute numbers of neutrophils and monocytes, and the levels of serum sTREM-1 were higher than those in smear negative patients. The absolute numbers of neutrophils and monocytes, and the levels of serum sTREM-1 decreased in ATB patients after anti-TB drug treatments. Serum sTREM-1 level ≥ 528.14 pg/mL was very useful to diagnosis the smear positive ATB, and the accuracy was 100%. Pearson correlation test revealed that the absolute numbers of neutrophils and monocytes were both positively correlated to the levels of serum sTREM-1. CONCLUSION: High serum levels of sTREM-1 may be of high value for early warning and prediction of poor prognosis in ATB patients.
OBJECTIVE: To investigate the role of serum soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) in patients with active pulmonary tuberculosis (ATB) and explore its clinical significance. METHODS: The study included 78 cases of ATBpatients and 40 cases of healthy volunteers from Dongguan Hospital for Chronic Diseases. Peripheral blood neutrophils and monocytes were counted by automated hematology analyzer. Serum sTREM-1 levels were detected by ELISA, and then the relevance with neutrophils and monocytes were analyzed by Pearson correlation test, respectively. RESULTS: The absolute numbers of neutrophils and monocytes, and the levels of serum sTREM-1 were higher in ATBpatients than those in normal controls. In smear positive patients, the absolute numbers of neutrophils and monocytes, and the levels of serum sTREM-1 were higher than those in smear negative patients. The absolute numbers of neutrophils and monocytes, and the levels of serum sTREM-1 decreased in ATBpatients after anti-TB drug treatments. Serum sTREM-1 level ≥ 528.14 pg/mL was very useful to diagnosis the smear positive ATB, and the accuracy was 100%. Pearson correlation test revealed that the absolute numbers of neutrophils and monocytes were both positively correlated to the levels of serum sTREM-1. CONCLUSION: High serum levels of sTREM-1 may be of high value for early warning and prediction of poor prognosis in ATBpatients.