Literature DB >> 25652735

Suppressing effect of cordycepin on the lipopolysaccharide-induced nitric oxide production in RAW 264.7 cells.

Kenta Imamura1, Momoko Asai, Kazuhiro Sugamoto, Tomoko Matsumoto, Yumi Yamasaki, Ichiro Kamei, Takahiro Hattori, Masaoki Kishimoto, Seiji Niisaka, Masaomi Kubo, Kazuo Nishiyama, Masao Yamasaki.   

Abstract

In this study, we focused on the anti-inflammatory effect of cordycepin, 3'-deoxyadenosine. Cordycepin potently suppressed nitric oxide production in lipopolysaccharide-stimulated RAW 264.7 cells in an adenosine receptor-independent manner. In addition, inhibitors for adenosine kinase and nucleoside transporter abrogated the action of cordycepin. Thus, we considered that intracellular metabolism cordycepin is important for the anti-inflammatory effect of cordycepin.

Entities:  

Keywords:  RAW 264.7 cells; adenosine kinase; adenosine receptor; cordycepin; nitric oxide

Mesh：

Substances：

Year:  2015        PMID： 25652735     DOI： 10.1080/09168451.2015.1008977

Source DB:  PubMed          Journal:  Biosci Biotechnol Biochem        ISSN： 0916-8451            Impact factor:   2.043


  6 in total

1.  Cordycepin inhibits vascular adhesion molecule expression in TNF-α-stimulated vascular muscle cells.

Authors:  Li-Jie Yan; Hai-Tao Yang; Hong-Yan Duan; Jin-Tao Wu; Peng Qian; Xian-Wei Fan; Shanling Wang
Journal:  Exp Ther Med       Date:  2017-07-09       Impact factor: 2.447

2.  Cordycepin promotes apoptosis in renal carcinoma cells by activating the MKK7-JNK signaling pathway through inhibition of c-FLIPL expression.

Authors:  In-Hu Hwang; Seung Yoon Oh; Hyun-Jin Jang; Eunbi Jo; Jong Cheon Joo; Kyung-Bok Lee; Hwa-Seung Yoo; Mi Young Lee; Soo Jung Park; Ik-Soon Jang
Journal:  PLoS One       Date:  2017-10-18       Impact factor: 3.240

3.  The polyadenylation inhibitor cordycepin reduces pain, inflammation and joint pathology in rodent models of osteoarthritis.

Authors:  Sadaf Ashraf; Masar Radhi; Peter Gowler; James J Burston; Raj D Gandhi; Graeme J Thorn; Anna M Piccinini; David A Walsh; Victoria Chapman; Cornelia H de Moor
Journal:  Sci Rep       Date:  2019-03-18       Impact factor: 4.379

Review 4.  A Systematic Review of the Biological Effects of Cordycepin.

Authors:  Masar Radhi; Sadaf Ashraf; Steven Lawrence; Asta Arendt Tranholm; Peter Arthur David Wellham; Abdul Hafeez; Ammar Sabah Khamis; Robert Thomas; Daniel McWilliams; Cornelia Huiberdina de Moor
Journal:  Molecules       Date:  2021-09-28       Impact factor: 4.411

5.  Onion (Allium cepa L.)-Derived Nanoparticles Inhibited LPS-Induced Nitrate Production, However, Their Intracellular Incorporation by Endocytosis Was Not Involved in This Effect on RAW264 Cells.

Authors:  Masao Yamasaki; Yumi Yamasaki; Rina Furusho; Hayaka Kimura; Ichiro Kamei; Hiroko Sonoda; Masahiro Ikeda; Tatsuya Oshima; Kenjiro Ogawa; Kazuo Nishiyama
Journal:  Molecules       Date:  2021-05-07       Impact factor: 4.411

6.  Cordycepin inhibits LPS-induced inflammatory and matrix degradation in the intervertebral disc.

Authors:  Yan Li; Kang Li; Lu Mao; Xiuguo Han; Kai Zhang; Changqing Zhao; Jie Zhao
Journal:  PeerJ       Date:  2016-05-10       Impact factor: 2.984
  6 in total

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