Literature DB >> 2565145

Effects of inhibitory and excitatory amino acid neurotransmitters on isolated cerebral parenchymal arterioles.

M Takayasu1, R G Dacey.   

Abstract

The vasoactive properties of inhibitory (gamma-aminobutyric acid (GABA), glycine) and excitatory (glutamate, aspartate) amino acid neurotransmitters were studied in isolated rat cerebral parenchymal arterioles. None of these neurotransmitters had a significant effect on vessel diameter at concentrations between 10(-9) and 10(-3) M, except for 10(-3) M glycine. These amino acid neurotransmitters are unlikely to play a role in regulation or pathophysiology of the cerebral microcirculation by directly changing vascular diameter.

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Year:  1989        PMID： 2565145     DOI： 10.1016/0006-8993(89)91207-9

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  7 in total

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Authors:  John P Bannister; Adebowale Adebiyi; Guiling Zhao; Damodaran Narayanan; Candice M Thomas; Jessie Y Feng; Jonathan H Jaggar
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  7 in total

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