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Literature DB >> 25651178

Muscle as a "mediator" of systemic metabolism.

Kedryn K Baskin¹, Benjamin R Winders², Eric N Olson³.

Abstract

Skeletal and cardiac muscles play key roles in the regulation of systemic energy homeostasis and display remarkable plasticity in their metabolic responses to caloric availability and physical activity. In this Perspective we discuss recent studies highlighting transcriptional mechanisms that govern systemic metabolism by striated muscles. We focus on the participation of the Mediator complex in this process, and suggest that tissue-specific regulation of Mediator subunits impacts metabolic homeostasis.

Entities: Chemical Disease Gene Species

Mesh：

Year: 2015 PMID： 25651178 PMCID： PMC4398026 DOI： 10.1016/j.cmet.2014.12.021

Source DB: PubMed Journal: Cell Metab ISSN： 1550-4131 Impact factor: 27.287

134 in total

Review 1. The human Mediator complex: a versatile, genome-wide regulator of transcription.

Authors: Dylan J Taatjes
Journal: Trends Biochem Sci Date: 2010-03-17 Impact factor: 13.807

Review 2. Cardiac metabolism in heart failure: implications beyond ATP production.

Authors: Torsten Doenst; Tien Dung Nguyen; E Dale Abel
Journal: Circ Res Date: 2013-08-30 Impact factor: 17.367

Review 3. Fiber types in mammalian skeletal muscles.

Authors: Stefano Schiaffino; Carlo Reggiani
Journal: Physiol Rev Date: 2011-10 Impact factor: 37.312

4. Activation of PPARgamma coactivator-1 through transcription factor docking.

Authors: P Puigserver; G Adelmant; Z Wu; M Fan; J Xu; B O'Malley; B M Spiegelman
Journal: Science Date: 1999-11-12 Impact factor: 47.728

5. MicroRNA-1 functions as a potential tumor suppressor in osteosarcoma by targeting Med1 and Med31.

Authors: Chaoyin Jiang; Hua Chen; Lei Shao; Qiaojie Wang
Journal: Oncol Rep Date: 2014-06-20 Impact factor: 3.906

Review 6. The role of hepatokines in metabolism.

Authors: Norbert Stefan; Hans-Ulrich Häring
Journal: Nat Rev Endocrinol Date: 2013-01-22 Impact factor: 43.330

7. The nuclear receptor ERRalpha is required for the bioenergetic and functional adaptation to cardiac pressure overload.

Authors: Janice M Huss; Ken-ichi Imahashi; Catherine R Dufour; Carla J Weinheimer; Michael Courtois; Atilla Kovacs; Vincent Giguère; Elizabeth Murphy; Daniel P Kelly
Journal: Cell Metab Date: 2007-07 Impact factor: 27.287

Review 8. Thyroid hormone regulation of metabolism.

Authors: Rashmi Mullur; Yan-Yun Liu; Gregory A Brent
Journal: Physiol Rev Date: 2014-04 Impact factor: 37.312

9. Nuclear receptor/microRNA circuitry links muscle fiber type to energy metabolism.

Authors: Zhenji Gan; John Rumsey; Bethany C Hazen; Ling Lai; Teresa C Leone; Rick B Vega; Hui Xie; Kevin E Conley; Johan Auwerx; Steven R Smith; Eric N Olson; Anastasia Kralli; Daniel P Kelly
Journal: J Clin Invest Date: 2013-05-08 Impact factor: 14.808

Review 10. Road to exercise mimetics: targeting nuclear receptors in skeletal muscle.

Authors: Weiwei Fan; Annette R Atkins; Ruth T Yu; Michael Downes; Ronald M Evans
Journal: J Mol Endocrinol Date: 2013-11-26 Impact factor: 5.098

71 in total

Review 1. The emerging role of skeletal muscle oxidative metabolism as a biological target and cellular regulator of cancer-induced muscle wasting.

Authors: James A Carson; Justin P Hardee; Brandon N VanderVeen
Journal: Semin Cell Dev Biol Date: 2015-12-01 Impact factor: 7.727

Review 2. Intramuscular Anabolic Signaling and Endocrine Response Following Resistance Exercise: Implications for Muscle Hypertrophy.

Authors: Adam M Gonzalez; Jay R Hoffman; Jeffrey R Stout; David H Fukuda; Darryn S Willoughby
Journal: Sports Med Date: 2016-05 Impact factor: 11.136

Muscle as a "mediator" of systemic metabolism.

Review 1. The human Mediator complex: a versatile, genome-wide regulator of transcription.

Review 2. Cardiac metabolism in heart failure: implications beyond ATP production.

Review 3. Fiber types in mammalian skeletal muscles.

4. Activation of PPARgamma coactivator-1 through transcription factor docking.

5. MicroRNA-1 functions as a potential tumor suppressor in osteosarcoma by targeting Med1 and Med31.

Review 6. The role of hepatokines in metabolism.

7. The nuclear receptor ERRalpha is required for the bioenergetic and functional adaptation to cardiac pressure overload.

Review 8. Thyroid hormone regulation of metabolism.

9. Nuclear receptor/microRNA circuitry links muscle fiber type to energy metabolism.

Review 10. Road to exercise mimetics: targeting nuclear receptors in skeletal muscle.

Review 1. The emerging role of skeletal muscle oxidative metabolism as a biological target and cellular regulator of cancer-induced muscle wasting.

Review 2. Intramuscular Anabolic Signaling and Endocrine Response Following Resistance Exercise: Implications for Muscle Hypertrophy.

Review 3. Metabolism and Skeletal Muscle Homeostasis in Lung Disease.

4. Cardiac Med1 deletion promotes early lethality, cardiac remodeling, and transcriptional reprogramming.

Review 5. Exploring inter-organ crosstalk to uncover mechanisms that regulate β-cell function and mass.

6. Electrical stimulation increases hypertrophy and metabolic flux in tissue-engineered human skeletal muscle.

7. Sex-specific, reciprocal regulation of ERα and miR-22 controls muscle lipid metabolism in male mice.

8. Muscle Directs Diurnal Energy Homeostasis through a Myokine-Dependent Hormone Module in Drosophila.

Review 9. Nutrient sensing and utilization: Getting to the heart of metabolic flexibility.

Review 10. Bone and Muscle Endocrine Functions: Unexpected Paradigms of Inter-organ Communication.