| Literature DB >> 25651170 |
Ling He1, Fredric E Wondisford2.
Abstract
Metformin has been used for nearly a century and is now the most widely prescribed oral anti-diabetic agent worldwide. Yet how metformin acts remains only partially understood and controversial. One key reason may be that almost all previous studies were conducted with supra-pharmacological concentrations (doses) of metformin, 10-100 times higher than maximally achievable therapeutic concentrations found in patients with type 2 diabetes mellitus.Entities:
Mesh：
Substances：
Year: 2015 PMID： 25651170 DOI： 10.1016/j.cmet.2015.01.003
Source DB: PubMed Journal: Cell Metab ISSN： 1550-4131 Impact factor: 27.287