Literature DB >> 25650850

Bioethical conflicts of gene therapy: a brief critical review.

José Ednésio da Cruz Freire1, Suelen Carneiro de Medeiros2, Antônio Viana Lopes Neto1, José Edvar Monteiro Júnior3, Antônio Juscelino Sudário Sousa1, Antônio José Rocha1, Léa Maria Bezerra de Menezes4.   

Abstract

Methods and techniques employed in gene therapy are reviewed in parallel with pertinent ethical conflicts. Clinical interventions based on gene therapy techniques preferentially use vectors for the transportation of therapeutic genes, however little is known about the potential risks and damages to the patient. Thus, attending carefully to the clinical complications arising as well as to security is essential. Despite the scientific and technological advances, there are still many uncertainties about the side effects of gene therapy. Moreover, there is a need, above all, to understand the principles of bioethics as both science and ethics, in accordance with its socioecological responsibility, in order to prioritize the health and welfare of man and nature, using properly natural resources and technology. Therefore, it is hard to determine objective results and to which extent the insertion of genes can affect the organism, as well as the ethical implication.

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Year:  2014        PMID: 25650850     DOI: 10.1590/1806-9282.60.06.008

Source DB:  PubMed          Journal:  Rev Assoc Med Bras (1992)        ISSN: 0104-4230            Impact factor:   1.209


  2 in total

Review 1.  Regulatory and Scientific Advancements in Gene Therapy: State-of-the-Art of Clinical Applications and of the Supporting European Regulatory Framework.

Authors:  Marta Carvalho; Bruno Sepodes; Ana Paula Martins
Journal:  Front Med (Lausanne)       Date:  2017-10-26

2.  Advanced therapy medicinal products: value judgement and ethical evaluation in health technology assessment.

Authors:  Elisabete Gonçalves
Journal:  Eur J Health Econ       Date:  2020-01-09
  2 in total

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