Elliot M Friedman1, Sharon L Christ2, Daniel K Mroczek3. 1. Purdue University, West Lafayette, IN, USA efriedman@purdue.edu. 2. Purdue University, West Lafayette, IN, USA. 3. Northwestern University, Evanston, IL, USA.
Abstract
OBJECTIVE: Older adults are increasingly likely to have two or more chronic medical conditions (multimorbidity) and are consequently at greater risk of disability. Here we examine the role of inflammation in mediating the relationship between multimorbidity and disability. METHOD: Data are from the Survey of Mid-Life in the United States (MIDUS), a national sample of middle-aged and older adults. Structural equation models were used to assess direct relationships between multimorbidity and activities of daily living as well as indirect associations with a latent variable for inflammation (indicated by circulating levels of interleukin-6, C-reactive protein, and fibrinogen) as a mediator. RESULTS: After adjustment for potential confounds, multimorbidity was positively associated with inflammation (p < .001) and functional limitations (p < .001), and inflammation partially mediated the link between multimorbidity and functional limitations (p < .01). DISCUSSION: Inflammation may be an important biological mechanism through which chronic medical conditions are linked to disability in later life.
OBJECTIVE: Older adults are increasingly likely to have two or more chronic medical conditions (multimorbidity) and are consequently at greater risk of disability. Here we examine the role of inflammation in mediating the relationship between multimorbidity and disability. METHOD: Data are from the Survey of Mid-Life in the United States (MIDUS), a national sample of middle-aged and older adults. Structural equation models were used to assess direct relationships between multimorbidity and activities of daily living as well as indirect associations with a latent variable for inflammation (indicated by circulating levels of interleukin-6, C-reactive protein, and fibrinogen) as a mediator. RESULTS: After adjustment for potential confounds, multimorbidity was positively associated with inflammation (p < .001) and functional limitations (p < .001), and inflammation partially mediated the link between multimorbidity and functional limitations (p < .01). DISCUSSION: Inflammation may be an important biological mechanism through which chronic medical conditions are linked to disability in later life.
Authors: Susan G Lakoski; Mary Cushman; Michael Criqui; Tatjana Rundek; Roger S Blumenthal; Ralph B D'Agostino; David M Herrington Journal: Am Heart J Date: 2006-09 Impact factor: 4.749
Authors: Mandip S Dhamoon; Ying-Kuen Cheung; Yeseon P Moon; Clinton B Wright; Joshua Z Willey; Ralph Sacco; Mitchell Sv Elkind Journal: Age Ageing Date: 2017-01-15 Impact factor: 10.668
Authors: Jennifer R Piazza; Natalia O Dmitrieva; Susan T Charles; David M Almeida; Gabriel A Orona Journal: Health Psychol Date: 2018-07-19 Impact factor: 4.267
Authors: A Calderón-Larrañaga; D L Vetrano; L Ferrucci; S W Mercer; A Marengoni; G Onder; M Eriksdotter; L Fratiglioni Journal: J Intern Med Date: 2018-11-22 Impact factor: 8.989