Literature DB >> 25649654

Heritability of cognitive traits among siblings with a parental history of Alzheimer's disease.

Burcu F Darst1, Rebecca L Koscik2, Bruce P Hermann2, Asenath La Rue2, Mark A Sager2, Sterling C Johnson3, Corinne D Engelman1.   

Abstract

Cognitive decline is one of the hallmark features of Alzheimer's disease, but many studies struggle to find strong associations between cognitive function and genetic variants. In order to identify which aspects of cognition are more likely to have a strong genetic component, we assessed the heritability of various cognitive functions related to Alzheimer's disease in 303 initially asymptomatic middle-aged adult siblings with a parental history of Alzheimer's disease from the Wisconsin Registry for Alzheimer's Prevention. Participants underwent extensive cognitive testing, and six cognitive factors were identified via factor analysis. Working Memory and Visual Learning & Memory had the highest heritability (52% and 41%, respectively). Inclusion of APOE allele counts did not notably change heritability estimates, indicating that there are likely additional genetic variants contributing to cognition. These findings suggest that future genetic studies should focus on the cognitive domains of Working Memory and Visual Learning & Memory.

Entities:  

Keywords:  APOE; Alzheimer's disease; WRAP; cognitive function; genetics; heritability

Mesh：

Substances：

Year:  2015        PMID： 25649654      PMCID： PMC4398625          DOI： 10.3233/JAD-142658

Source DB:  PubMed          Journal:  J Alzheimers Dis        ISSN： 1387-2877            Impact factor:   4.472


  18 in total

1.  Heritability and genetic association analysis of cognition in the Diabetes Heart Study.

Authors:  Amanda J Cox; Christina E Hugenschmidt; Laura M Raffield; Carl D Langefeld; Barry I Freedman; Jeff D Williamson; Fang-Chi Hsu; Donald W Bowden
Journal:  Neurobiol Aging       Date:  2014-03-11       Impact factor: 4.673

2.  Middle-aged children of persons with Alzheimer's disease: APOE genotypes and cognitive function in the Wisconsin Registry for Alzheimer's Prevention.

Authors:  Mark A Sager; Bruce Hermann; Asenath La Rue
Journal:  J Geriatr Psychiatry Neurol       Date:  2005-12       Impact factor: 2.680

Review 3.  Neuropsychological and neuroimaging changes in preclinical Alzheimer's disease.

Authors:  Elizabeth W Twamley; Susan A Legendre Ropacki; Mark W Bondi
Journal:  J Int Neuropsychol Soc       Date:  2006-09       Impact factor: 2.892

4.  Multipoint quantitative-trait linkage analysis in general pedigrees.

Authors:  L Almasy; J Blangero
Journal:  Am J Hum Genet       Date:  1998-05       Impact factor: 11.025

5.  Genetic susceptibility to accelerated cognitive decline in the US Health and Retirement Study.

Authors:  Chenan Zhang; Brandon L Pierce
Journal:  Neurobiol Aging       Date:  2013-12-26       Impact factor: 4.673

6.  Variability and stability in cognitive abilities are largely genetic later in life.

Authors:  R Plomin; N L Pedersen; P Lichtenstein; G E McClearn
Journal:  Behav Genet       Date:  1994-05       Impact factor: 2.805

7.  Origins of individual differences in episodic memory in the oldest-old: a population-based study of identical and same-sex fraternal twins aged 80 and older.

Authors:  B Johansson; K Whitfield; N L Pedersen; S M Hofer; F Ahern; G E McClearn
Journal:  J Gerontol B Psychol Sci Soc Sci       Date:  1999-05       Impact factor: 4.077

8.  Emergence of mild cognitive impairment in late middle-aged adults in the wisconsin registry for Alzheimer's prevention.

Authors:  Rebecca L Koscik; Asenath La Rue; Erin M Jonaitis; Ozioma C Okonkwo; Sterling C Johnson; Barbara B Bendlin; Bruce P Hermann; Mark A Sager
Journal:  Dement Geriatr Cogn Disord       Date:  2014-02-20       Impact factor: 2.959

9.  Genetic influences on memory performance in familial Alzheimer disease.

Authors:  J H Lee; A Flaquer; Y Stern; B Tycko; R Mayeux
Journal:  Neurology       Date:  2004-02-10       Impact factor: 9.910

10.  Effect of parental family history of Alzheimer's disease on serial position profiles.

Authors:  Asenath La Rue; Bruce Hermann; Jana E Jones; Sterling Johnson; Sanjay Asthana; Mark A Sager
Journal:  Alzheimers Dement       Date:  2008-07       Impact factor: 21.566
View more
  6 in total

1.  Stressful Life Events and Racial Disparities in Cognition Among Middle-Aged and Older Adults.

Authors:  Megan Zuelsdorff; Ozioma C Okonkwo; Derek Norton; Lisa L Barnes; Karen L Graham; Lindsay R Clark; Mary F Wyman; Susan F Benton; Alexander Gee; Nickolas Lambrou; Sterling C Johnson; Carey E Gleason
Journal:  J Alzheimers Dis       Date:  2020       Impact factor: 4.472

2.  Pathway-Specific Polygenic Risk Scores as Predictors of Amyloid-β Deposition and Cognitive Function in a Sample at Increased Risk for Alzheimer's Disease.

Authors:  Burcu F Darst; Rebecca L Koscik; Annie M Racine; Jennifer M Oh; Rachel A Krause; Cynthia M Carlsson; Henrik Zetterberg; Kaj Blennow; Bradley T Christian; Barbara B Bendlin; Ozioma C Okonkwo; Kirk J Hogan; Bruce P Hermann; Mark A Sager; Sanjay Asthana; Sterling C Johnson; Corinne D Engelman
Journal:  J Alzheimers Dis       Date:  2017       Impact factor: 4.472

3.  Social support and verbal interaction are differentially associated with cognitive function in midlife and older age.

Authors:  Megan L Zuelsdorff; Rebecca L Koscik; Ozioma C Okonkwo; Paul E Peppard; Bruce P Hermann; Mark A Sager; Sterling C Johnson; Corinne D Engelman
Journal:  Neuropsychol Dev Cogn B Aging Neuropsychol Cogn       Date:  2017-12-15

4.  The Factor Structure of Cognitive Functioning in Cognitively Healthy Participants: a Meta-Analysis and Meta-Analysis of Individual Participant Data.

Authors:  Joost A Agelink van Rentergem; Nathalie R de Vent; Ben A Schmand; Jaap M J Murre; Janneke P C Staaks; Hilde M Huizenga
Journal:  Neuropsychol Rev       Date:  2020-02-01       Impact factor: 7.444

5.  The effect of rare variants in TREM2 and PLD3 on longitudinal cognitive function in the Wisconsin Registry for Alzheimer's Prevention.

Authors:  Corinne D Engelman; Burcu F Darst; Murat Bilgel; Eva Vasiljevic; Rebecca L Koscik; Bruno M Jedynak; Sterling C Johnson
Journal:  Neurobiol Aging       Date:  2017-12-29       Impact factor: 4.673

6.  Modeling practice effects in healthy middle-aged participants of the Alzheimer and Families parent cohort.

Authors:  Gonzalo Sánchez-Benavides; Juan D Gispert; Karine Fauria; José Luis Molinuevo; Nina Gramunt
Journal:  Alzheimers Dement (Amst)       Date:  2016-08-30
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.