Literature DB >> 25649528

Shape-Dependent Targeting of Injured Blood Vessels by Peptide Amphiphile Supramolecular Nanostructures.

Tyson J Moyer1,2, Hussein A Kassam1,3, Edward S M Bahnson1,3, Courtney E Morgan1,3, Faifan Tantakitti1,2, Teng L Chew1,4, Melina R Kibbe1,3, Samuel I Stupp1,2,4,5.   

Abstract

Targeting of vascular intervention by systemically delivered supramolecular nanofibers after balloon angioplasty is described. Tracking of self-assembling peptide amphiphiles using fluorescence shows selective binding to the site of vascular intervention. Cylindrical nanostructures are observed to target the site of arterial injury, while spherical nanostructures with an equivalent diameter display no binding.
© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Entities:  

Keywords:  peptides; self-assembly; supramolecular chemistry; vascular targeting

Mesh：

Substances：

Year:  2015        PMID： 25649528      PMCID： PMC4478239          DOI： 10.1002/smll.201403429

Source DB:  PubMed          Journal:  Small        ISSN： 1613-6810            Impact factor:   13.281


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