BACKGROUND/ OBJECTIVES: High salt intake is a well-recognized risk factor of osteoporosis for its modulating effect on calcium metabolism. To understand the effect of dietary sodium on bone turnover, we evaluated the association between urinary sodium excretion and bone turnover markers in Korean postmenopausal women with low bone mass. SUBJECTS/ METHODS: A retrospective review of medical records at a single institution identified 537 postmenopausal women who were first diagnosed with osteopenia or osteoporosis between 2008 and 2013. Subjects were stratified by low (<2 g/day, n=77), moderate (2-4.4 g/day, n=354) and high (⩾4.4 g/day, n=106) sodium excretion. A 24-h urine was collected to estimate sodium, calcium and creatinine. Bone turnover markers and calciotropic hormones were measured in serum. Bone mineral density (BMD) was assessed using dual-energy X-ray absorptiometry. RESULTS: Sodium intake was positively associated with urinary sodium excretion (P=0.006, r=0.29). Bone turnover markers were significantly higher in the moderate-to-high urinary sodium excretion group (⩾2 g/day) than in the low urinary sodium excretion group (<2 g/day); CTX-I (C-telopeptides of type I collagen) was 21.3% higher (P=0.001) and osteocalcin (OC) was 15.7% higher (P=0.004). Calciotropic hormones and BMD were not significantly different across the sodium excretion groups. CONCLUSIONS: High urinary sodium excretion (⩾2 g/day) increased bone turnover markers in Korean postmenopausal women, suggesting that excessive sodium intake might accelerate bone turnover.
BACKGROUND/ OBJECTIVES: High salt intake is a well-recognized risk factor of osteoporosis for its modulating effect on calcium metabolism. To understand the effect of dietary sodium on bone turnover, we evaluated the association between urinary sodium excretion and bone turnover markers in Korean postmenopausal women with low bone mass. SUBJECTS/ METHODS: A retrospective review of medical records at a single institution identified 537 postmenopausal women who were first diagnosed with osteopenia or osteoporosis between 2008 and 2013. Subjects were stratified by low (<2 g/day, n=77), moderate (2-4.4 g/day, n=354) and high (⩾4.4 g/day, n=106) sodium excretion. A 24-h urine was collected to estimate sodium, calcium and creatinine. Bone turnover markers and calciotropic hormones were measured in serum. Bone mineral density (BMD) was assessed using dual-energy X-ray absorptiometry. RESULTS:Sodium intake was positively associated with urinary sodium excretion (P=0.006, r=0.29). Bone turnover markers were significantly higher in the moderate-to-high urinary sodium excretion group (⩾2 g/day) than in the low urinary sodium excretion group (<2 g/day); CTX-I (C-telopeptides of type I collagen) was 21.3% higher (P=0.001) and osteocalcin (OC) was 15.7% higher (P=0.004). Calciotropic hormones and BMD were not significantly different across the sodium excretion groups. CONCLUSIONS: High urinary sodium excretion (⩾2 g/day) increased bone turnover markers in Korean postmenopausal women, suggesting that excessive sodium intake might accelerate bone turnover.
Authors: Paul K Whelton; Lawrence J Appel; Ralph L Sacco; Cheryl A M Anderson; Elliott M Antman; Norman Campbell; Sandra B Dunbar; Edward D Frohlich; John E Hall; Mariell Jessup; Darwin R Labarthe; Graham A MacGregor; Frank M Sacks; Jeremiah Stamler; Dorothea K Vafiadis; Linda V Van Horn Journal: Circulation Date: 2012-11-02 Impact factor: 29.690
Authors: Laura D Carbone; Karen D Barrow; Andrew J Bush; M David Boatright; Jean A Michelson; Kathleen A Pitts; Victorina N Pintea; Andrew H Kang; Mitchell A Watsky Journal: J Bone Miner Metab Date: 2005 Impact factor: 2.626
Authors: Marc C Hochberg; Susan Greenspan; Richard D Wasnich; Paul Miller; Desmond E Thompson; Philip D Ross Journal: J Clin Endocrinol Metab Date: 2002-04 Impact factor: 5.958
Authors: Birgit Teucher; Jack R Dainty; Caroline A Spinks; Gosia Majsak-Newman; David J Berry; Jurian A Hoogewerff; Robert J Foxall; Jette Jakobsen; Kevin D Cashman; Albert Flynn; Susan J Fairweather-Tait Journal: J Bone Miner Res Date: 2008-09 Impact factor: 6.741
Authors: Katherine J Overwyk; Zerleen S Quader; Joyce Maalouf; Marlana Bates; Jacqui Webster; Mary G George; Robert K Merritt; Mary E Cogswell Journal: Adv Nutr Date: 2020-09-01 Impact factor: 8.701
Authors: Roghayeh Chenary; Akram Karimi-Shahanjarini; Saeed Bashirian; Ghodratollah Roshanaei; Ali Akbar Fazaeli; Ali Mohammadimanesh; Mohsen Jalilian Journal: J Res Health Sci Date: 2020-09-30
Authors: Christian Adolf; Leah T Braun; Carmina T Fuss; Stefanie Hahner; Heike Künzel; Laura Handgriff; Lisa Sturm; Daniel A Heinrich; Holger Schneider; Martin Bidlingmaier; Martin Reincke Journal: Endocrine Date: 2020-06-27 Impact factor: 3.633
Authors: Eleftherios Veniamakis; Georgios Kaplanis; Panagiotis Voulgaris; Pantelis T Nikolaidis Journal: Int J Environ Res Public Health Date: 2022-03-19 Impact factor: 3.390