Literature DB >> 25648900

Designing nanomolar antagonists of DC-SIGN-mediated HIV infection: ligand presentation using molecular rods.

Stefania Ordanini1, Norbert Varga, Vanessa Porkolab, Michel Thépaut, Laura Belvisi, Andrea Bertaglia, Alessandro Palmioli, Angela Berzi, Daria Trabattoni, Mario Clerici, Franck Fieschi, Anna Bernardi.   

Abstract

DC-SIGN antagonists were designed combining one selective monovalent glycomimetic ligand with trivalent dendrons separated by a rigid core of controlled length. The design combines multiple multivalency effects to achieve inhibitors of HIV infection, which are active in nanomolar concentration.

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Year:  2015        PMID： 25648900     DOI： 10.1039/c4cc09709b

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  19 in total

1.  Chemical and Biophysical Approaches for Complete Characterization of Lectin-Carbohydrate Interactions.

Authors:  Sabrina Lusvarghi; Rodolfo Ghirlando; Jack R Davison; Carole A Bewley
Journal:  Methods Enzymol       Date:  2017-07-23       Impact factor: 1.600

2.  Multivalent Cluster Nanomolecules for Inhibiting Protein-Protein Interactions.

Authors:  Elaine A Qian; Yanxiao Han; Marco S Messina; Heather D Maynard; Petr Král; Alexander M Spokoyny
Journal:  Bioconjug Chem       Date:  2019-09-23       Impact factor: 4.774

Review 3.  Baseline and time-updated factors in preclinical development of anionic dendrimers as successful anti-HIV-1 vaginal microbicides.

Authors:  Ignacio Rodríguez-Izquierdo; Daniel Sepúlveda-Crespo; Jose María Lasso; Salvador Resino; Ma Ángeles Muñoz-Fernández
Journal:  Wiley Interdiscip Rev Nanomed Nanobiotechnol       Date:  2022-01-12

4.  Pseudo-Mannosylated DC-SIGN Ligands as Immunomodulants.

Authors:  Angela Berzi; Stefania Ordanini; Ben Joosten; Daria Trabattoni; Alessandra Cambi; Anna Bernardi; Mario Clerici
Journal:  Sci Rep       Date:  2016-10-13       Impact factor: 4.379

5.  Linear biocompatible glyco-polyamidoamines as dual action mode virus infection inhibitors with potential as broad-spectrum microbicides for sexually transmitted diseases.

Authors:  Nicolò Mauro; Paolo Ferruti; Elisabetta Ranucci; Amedea Manfredi; Angela Berzi; Mario Clerici; Valeria Cagno; David Lembo; Alessandro Palmioli; Sara Sattin
Journal:  Sci Rep       Date:  2016-09-19       Impact factor: 4.379

Review 6.  Myeloid C-Type Lectin Receptors in Viral Recognition and Antiviral Immunity.

Authors:  João T Monteiro; Bernd Lepenies
Journal:  Viruses       Date:  2017-03-22       Impact factor: 5.048

7.  Multivalency Increases the Binding Strength of RGD Peptidomimetic-Paclitaxel Conjugates to Integrin αV β3.

Authors:  André Raposo Moreira Dias; Arianna Pina; Alberto Dal Corso; Daniela Arosio; Laura Belvisi; Luca Pignataro; Michele Caruso; Cesare Gennari
Journal:  Chemistry       Date:  2017-09-06       Impact factor: 5.236

8.  On-Chip Screening of a Glycomimetic Library with C-Type Lectins Reveals Structural Features Responsible for Preferential Binding of Dectin-2 over DC-SIGN/R and Langerin.

Authors:  Laura Medve; Silvia Achilli; Sonia Serna; Fabio Zuccotto; Norbert Varga; Michel Thépaut; Monica Civera; Corinne Vivès; Franck Fieschi; Niels Reichardt; Anna Bernardi
Journal:  Chemistry       Date:  2018-09-03       Impact factor: 5.236

9.  Double-Modified Glycopolymers from Thiolactones to Modulate Lectin Selectivity and Affinity.

Authors:  Laura E Wilkins; Nezha Badi; Filip Du Prez; Matthew I Gibson
Journal:  ACS Macro Lett       Date:  2018-12-06       Impact factor: 6.903

10.  Externally controllable glycan presentation on nanoparticle surfaces to modulate lectin recognition.

Authors:  Sangho Won; Sarah-Jane Richards; Marc Walker; Matthew I Gibson
Journal:  Nanoscale Horiz       Date:  2016-12-14       Impact factor: 10.989
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