Jiu-Yao Wang1, Shyh-Dar Shyur2, Frada Wei-Sam Lam3, Lawrence Shih-Hsin Wu4. 1. Department of Pediatrics and Institute of Molecular Medicine, College of Medicine, National Cheng-Kung University, Tainan, Taiwan. 2. Department of Pediatrics, Mackay Memorial Hospital, Taipei, Taiwan. 3. Division of Research Development, Vita Genomics Inc., Taipei, Taiwan. 4. Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan. Electronic address: lshwu@mail.tcu.edu.tw.
Abstract
BACKGROUND: The EHF and ELF5 genes, located on chromosome 11p and linked to asthma phenotypes, are high-potential candidate genes conferring asthma susceptibility. The purpose of this study was to investigate the genetic association among single nucleotide polymorphisms (SNPs) of EHF and ELF5, and their relationship with asthma in the Taiwanese population. METHODS: We selected and performed genotyping on 16 SNPs that encompass the genomic region of EHF and ELF5 in Taiwanese children with or without asthma. A total of 1983 children, 523 in the test group and 619 and 842 in two validation groups, were recruited for this study. RESULTS: The SNP rs3910901, located in the 5' upstream region of ELF5, was found to have a weak association (p = 0.043) with asthma in the odds ratio analysis. The genotype distribution was similar in all comparison groups, but the CC genotype was more frequent in asthma patients. Logistic regression adjusted allergy comorbidity showed obviously diluted association. CONCLUSION: The results indicated that SNP rs3910901 may have a minor impact on pediatric asthma in the Taiwanese population.
BACKGROUND: The EHF and ELF5 genes, located on chromosome 11p and linked to asthma phenotypes, are high-potential candidate genes conferring asthma susceptibility. The purpose of this study was to investigate the genetic association among single nucleotide polymorphisms (SNPs) of EHF and ELF5, and their relationship with asthma in the Taiwanese population. METHODS: We selected and performed genotyping on 16 SNPs that encompass the genomic region of EHF and ELF5 in Taiwanese children with or without asthma. A total of 1983 children, 523 in the test group and 619 and 842 in two validation groups, were recruited for this study. RESULTS: The SNP rs3910901, located in the 5' upstream region of ELF5, was found to have a weak association (p = 0.043) with asthma in the odds ratio analysis. The genotype distribution was similar in all comparison groups, but the CC genotype was more frequent in asthmapatients. Logistic regression adjusted allergy comorbidity showed obviously diluted association. CONCLUSION: The results indicated that SNP rs3910901 may have a minor impact on pediatric asthma in the Taiwanese population.
Authors: Dandan Sun; Liping Sun; Qian Xu; Yuehua Gong; Honghu Wang; Jun Yang; Yuan Yuan Journal: Int J Environ Res Public Health Date: 2016-03-04 Impact factor: 3.390