Literature DB >> 25648108

Myasthenia gravis mimicking stroke: a case series with sudden onset dysarthria.

Lucio Tremolizzo1, Federico Giopato, Maria Luisa Piatti, Andrea Rigamonti, Carlo Ferrarese, Ildebrando Appollonio.   

Abstract

Myasthenia gravis (MG) is an immune-mediated disorder characterized by fluctuating fatigue of skeletal muscles, often involving extrinsic ocular or bulbar districts. Myasthenia gravis in the elderly is an under-recognized condition, sometimes confused with cerebrovascular disease. Here we present a case series of myasthenia patients which onset was characterized by sudden dysarthria, clearly raising this diagnostic dilemma. In the workout of sudden onset isolated dysarthria, MG should be always considered. In fact, even if myasthenia is a rare condition, lacunar stroke only with this clinical presentation is also unusual, and significant risks may arise (e.g., unexpected myasthenic crisis).

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Year:  2015        PMID: 25648108     DOI: 10.1007/s10072-015-2098-0

Source DB:  PubMed          Journal:  Neurol Sci        ISSN: 1590-1874            Impact factor:   3.307


  22 in total

1.  Myasthenia gravis: an elusive diagnosis in older people.

Authors:  J K Ngeh; G McElligott
Journal:  J Am Geriatr Soc       Date:  2001-05       Impact factor: 5.562

2.  Clinical study of 227 patients with lacunar infarcts.

Authors:  A Arboix; J L Martí-Vilalta; J H García
Journal:  Stroke       Date:  1990-06       Impact factor: 7.914

Review 3.  Bulbar presentations of myasthenia gravis in the elderly patient.

Authors:  H R Sharp; A Degrip; D B Mitchell; A Heller
Journal:  J Laryngol Otol       Date:  2001-01       Impact factor: 1.469

4.  Isolated dysarthria due to extracerebellar lacunar stroke: a central monoparesis of the tongue.

Authors:  P P Urban; S Wicht; H C Hopf; S Fleischer; O Nickel
Journal:  J Neurol Neurosurg Psychiatry       Date:  1999-04       Impact factor: 10.154

5.  Myasthenia gravis and elderly people.

Authors:  F Schon; M Drayson; R A Thompson
Journal:  Age Ageing       Date:  1996-01       Impact factor: 10.668

6.  Myasthenia gravis as a 'stroke mimic'--it's all in the history.

Authors:  Saiffuddin Shaik; Mian Ayaz Ul-Haq; Hedley C A Emsley
Journal:  Clin Med (Lond)       Date:  2014-12       Impact factor: 2.659

7.  Evidence of underdiagnosis of myasthenia gravis in older people.

Authors:  A Vincent; L Clover; C Buckley; J Grimley Evans; P M Rothwell
Journal:  J Neurol Neurosurg Psychiatry       Date:  2003-08       Impact factor: 10.154

8.  Dysphagia in elderly men with myasthenia gravis.

Authors:  K J Kluin; M B Bromberg; E L Feldman; Z Simmons
Journal:  J Neurol Sci       Date:  1996-06       Impact factor: 3.181

9.  Myasthenia gravis mimicking stroke in elderly patients.

Authors:  G Kleiner-Fisman; H S Kott
Journal:  Mayo Clin Proc       Date:  1998-11       Impact factor: 7.616

10.  Different characteristic phenotypes according to antibody in myasthenia gravis.

Authors:  Shin J Oh; Marla B Morgan; Liang Lu; Yuki Hatanaka; Shoji Hemmi; Angela Young; Gwendolyn C Claussen
Journal:  J Clin Neuromuscul Dis       Date:  2012-12
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  2 in total

1.  Asymmetric pattern in generalized myasthenia gravis: A case report.

Authors:  Thiago Pereira de Carvalho; Clara Louise Vianna; Felipe Freitas Andrade; Rafaela Abreu Alvarenga; Liz de Oliveira Moura Sales; Rosana Souza Rodrigues; Paulo Henrique Rosado-de-Castro
Journal:  Medicine (Baltimore)       Date:  2018-12       Impact factor: 1.817

Review 2.  Isolated dysarthria as the sole manifestation of myasthenia gravis: a case report.

Authors:  Wei Li; Ling He; Xiaodong Jin; Li Li; Congcong Sun; Cuilan Wang
Journal:  J Int Med Res       Date:  2022-07       Impact factor: 1.573

  2 in total

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