Effect of Change of Mechanical Ventilation Position on the Treatment of Neonatal Respiratory Failure.

The aim of the study was to evaluate the effect of different ventilation positions in newborn infants with respiratory failure. A total of 67 newborn infant cases with respiratory failure were treated in neonatal intensive care unit of Xuzhou Central Hospital from February 2012 to August 2013. These infants were randomly divided into supine group (n = 33) and different position group (n = 34). Supine position for 4 h and prone position for 4 h were alternated in different position group. The results for 8 and 16 h ventilator parameters: oxygenation index OI (OI = PaO2/FiO2), the lung mechanics parameters, ventilator weaning time, arterial carbon dioxide partial pressure (PaCO2), and arterial oxygen tension (PaO2) after 1 h of ventilator weaning were recorded and compared. PaO2 in the different position ventilation groups for 8 h (65.29 ± 7.62 mm Hg) and 16 h (67.52 ± 9.31 mm Hg) were correspondingly higher than PaO2 at 8 h (60.13 ± 8.95 mm Hg) and 16 h (62.22 ± 10.83 mm Hg) in the supine position ventilation group, and the difference was statistically significant (P < 0.05), whereas OI at 8 h (166.95 ± 25.27 mm Hg) and 16 h (169.59 ± 20.28 mm Hg) in the former group was correspondingly higher than the OI at 8 h (150.16 ± 20.51 mm Hg) and 16 h (152.23 ± 22.45 mm Hg) in the latter group, and the difference was statistically significant (P < 0.05). The ventilator weaning time of the two groups and the change in the PaCO2 and PaO2, an hour after ventilator weaning was very similar and the difference was not statistically significant (P > 0.05). The symptoms of respiratory failure and oxygenation can be effectively improved in the newborn infants with different ventilation positions compared to traditional supine position.

RCT Entities:   Population Interventions Outcomes