Literature DB >> 25645910

Beyond mitochondria, what would be the energy source of the cell?

Arturo S Herrera, Maria Del C A Esparza, Ghulam Md Ashraf, Andrey A Zamyatnin, Gjumrakch Aliev1.   

Abstract

Currently, cell biology is based on glucose as the main source of energy. Cellular bioenergetic pathways have become unnecessarily complex in their eagerness to explain that how the cell is able to generate and use energy from the oxidation of glucose, where mitochondria play an important role through oxidative phosphorylation. During a descriptive study about the three leading causes of blindness in the world, the ability of melanin to transform light energy into chemical energy through the dissociation of water molecule was unraveled. Initially, during 2 or 3 years; we tried to link together our findings with the widely accepted metabolic pathways already described in metabolic pathway databases, which have been developed to collect and organize the current knowledge on metabolism scattered across a multitude of scientific articles. However, firstly, the literature on metabolism is extensive but rarely conclusive evidence is available, and secondly, one would expect these databases to contain largely the same information, but the contrary is true. For the apparently well studied metabolic process Krebs cycle, which was described as early as 1937 and is found in nearly every biology and chemistry curriculum, there is a considerable disagreement between at least five databases. Of the nearly 7000 reactions contained jointly by these five databases, only 199 are described in the same way in all the five databases. Thus to try to integrate chemical energy from melanin with the supposedly well-known bioenergetic pathways is easier said than done; and the lack of consensus about metabolic network constitutes an insurmountable barrier. After years of unsuccessful results, we finally realized that the chemical energy released through the dissociation of water molecule by melanin represents over 90% of cell energy requirements. These findings reveal a new aspect of cell biology, as glucose and ATP have biological functions related mainly to biomass and not so much with energy. Our finding about the unexpected intrinsic property of melanin to transform photon energy into chemical energy through the dissociation of water molecule, a role performed supposedly only by chlorophyll in plants, seriously questions the sacrosanct role of glucose and thereby mitochondria as the primary source of energy and power for the cells.

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Year:  2015        PMID: 25645910     DOI: 10.2174/1871524915666150203093656

Source DB:  PubMed          Journal:  Cent Nerv Syst Agents Med Chem        ISSN: 1871-5249


  4 in total

1.  Mitochondria as a Platform for Dictating the Cell Fate of Cultured Human Corneal Endothelial Cells.

Authors:  Kohsaku Numa; Morio Ueno; Tomoko Fujita; Koji Ueda; Nao Hiramoto; Atushi Mukai; Yuichi Tokuda; Masakazu Nakano; Chie Sotozono; Shigeru Kinoshita; Junji Hamuro
Journal:  Invest Ophthalmol Vis Sci       Date:  2020-12-01       Impact factor: 4.799

2.  Metabolites Interrogation in Cell Fate Decision of Cultured Human Corneal Endothelial Cells.

Authors:  Junji Hamuro; Kohsaku Numa; Tomoko Fujita; Munetoyo Toda; Koji Ueda; Yuichi Tokuda; Atushi Mukai; Masakazu Nakano; Morio Ueno; Shigeru Kinoshita; Chie Sotozono
Journal:  Invest Ophthalmol Vis Sci       Date:  2020-02-07       Impact factor: 4.799

Review 3.  The Long-Term Effect of Medically Enhancing Melanin Intrinsic Bioenergetics Capacity in Prematurity.

Authors:  Arturo S Herrera; Paola E Solís Arias; María Del C A Esparza; Luis F T Bernal; Andrey D Bondarev; Vladimir P Fisenko; Vladimir N Chubarev; Nina N Minyaeva; Liudmila M Mikhaleva; Vadim V Tarasov; Siva G Somasundaram; Cecil E Kirkland; Gjumrakch Aliev
Journal:  Curr Genomics       Date:  2020-11       Impact factor: 2.236

4.  COX5B-Mediated Bioenergetic Alterations Modulate Cell Growth and Anticancer Drug Susceptibility by Orchestrating Claudin-2 Expression in Colorectal Cancers.

Authors:  Yu-De Chu; Siew-Na Lim; Chau-Ting Yeh; Wey-Ran Lin
Journal:  Biomedicines       Date:  2021-12-28
  4 in total

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