Literature DB >> 25645860

Pancreatic cancer-associated diabetes is an "exosomopathy".

Murray Korc1.   

Abstract

Diabetes may be a consequence of pancreatic cancer, preceding cancer diagnosis. The underlying mechanism is the release of exosomes delivering adrenomedullin to β cells, inducing endoplasmic reticulum stress and perturbations in the unfolded protein response, leading to β-cell dysfunction and death. This knowledge could lead to improved diagnostic strategies for pancreatic cancer. ©2015 American Association for Cancer Research.

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Year:  2015        PMID： 25645860      PMCID： PMC4383672          DOI： 10.1158/1078-0432.CCR-14-2990

Source DB:  PubMed          Journal:  Clin Cancer Res        ISSN： 1078-0432            Impact factor:   12.531


  11 in total

Review 1.  Adrenomedullin: receptor and signal transduction.

Authors:  D M Smith; H A Coppock; D J Withers; A A Owji; D L Hay; T P Choksi; P Chakravarty; S Legon; D R Poyner
Journal:  Biochem Soc Trans       Date:  2002-08       Impact factor: 5.407

Review 2.  Targeting the unfolded protein response in disease.

Authors:  Claudio Hetz; Eric Chevet; Heather P Harding
Journal:  Nat Rev Drug Discov       Date:  2013-09       Impact factor: 84.694

Review 3.  New insights into pancreatic cancer-induced paraneoplastic diabetes.

Authors:  Raghuwansh P Sah; Sajan Jiv Singh Nagpal; Debabrata Mukhopadhyay; Suresh T Chari
Journal:  Nat Rev Gastroenterol Hepatol       Date:  2013-03-26       Impact factor: 46.802

4.  Projecting cancer incidence and deaths to 2030: the unexpected burden of thyroid, liver, and pancreas cancers in the United States.

Authors:  Lola Rahib; Benjamin D Smith; Rhonda Aizenberg; Allison B Rosenzweig; Julie M Fleshman; Lynn M Matrisian
Journal:  Cancer Res       Date:  2014-06-01       Impact factor: 12.701

5.  Pancreatic Cancer-Derived Exosomes Cause Paraneoplastic β-cell Dysfunction.

Authors:  Naureen Javeed; Gunisha Sagar; Shamit K Dutta; Thomas C Smyrk; Julie S Lau; Santanu Bhattacharya; Mark Truty; Gloria M Petersen; Randal J Kaufman; Suresh T Chari; Debabrata Mukhopadhyay
Journal:  Clin Cancer Res       Date:  2014-10-29       Impact factor: 12.531

6.  The economic burden of elevated blood glucose levels in 2012: diagnosed and undiagnosed diabetes, gestational diabetes mellitus, and prediabetes.

Authors:  Timothy M Dall; Wenya Yang; Pragna Halder; Bo Pang; Marjan Massoudi; Neil Wintfeld; April P Semilla; Jerry Franz; Paul F Hogan
Journal:  Diabetes Care       Date:  2014-12       Impact factor: 19.112

7.  Plasma levels of adrenomedullin, a newly identified hypotensive peptide, in patients with hypertension and renal failure.

Authors:  T Ishimitsu; T Nishikimi; Y Saito; K Kitamura; T Eto; K Kangawa; H Matsuo; T Omae; H Matsuoka
Journal:  J Clin Invest       Date:  1994-11       Impact factor: 14.808

8.  Prevalence and clinical profile of pancreatic cancer-associated diabetes mellitus.

Authors:  Rahul Pannala; Jeffery B Leirness; William R Bamlet; Ananda Basu; Gloria M Petersen; Suresh T Chari
Journal:  Gastroenterology       Date:  2008-01-18       Impact factor: 22.682

9.  A pilot study to develop a diagnostic test for pancreatic ductal adenocarcinoma based on differential expression of select miRNA in plasma and bile.

Authors:  Gregory A Cote; A Jesse Gore; Samantha D McElyea; Laura E Heathers; Huiping Xu; Stuart Sherman; Murray Korc
Journal:  Am J Gastroenterol       Date:  2014-10-28       Impact factor: 10.864

Review 10.  The relationship between diabetes and pancreatic cancer.

Authors:  Feng Wang; Margery Herrington; Jörgen Larsson; Johan Permert
Journal:  Mol Cancer       Date:  2003-01-06       Impact factor: 27.401
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  7 in total

Review 1.  Type 3c (pancreatogenic) diabetes mellitus secondary to chronic pancreatitis and pancreatic cancer.

Authors:  Phil A Hart; Melena D Bellin; Dana K Andersen; David Bradley; Zobeida Cruz-Monserrate; Christopher E Forsmark; Mark O Goodarzi; Aida Habtezion; Murray Korc; Yogish C Kudva; Stephen J Pandol; Dhiraj Yadav; Suresh T Chari
Journal:  Lancet Gastroenterol Hepatol       Date:  2016-10-12

Review 2.  Minireview: Emerging Roles for Extracellular Vesicles in Diabetes and Related Metabolic Disorders.

Authors:  Alexander J Lakhter; Emily K Sims
Journal:  Mol Endocrinol       Date:  2015-09-22

3.  Advances in Biomedical Imaging, Bioengineering, and Related Technologies for the Development of Biomarkers of Pancreatic Disease: Summary of a National Institute of Diabetes and Digestive and Kidney Diseases and National Institute of Biomedical Imaging and Bioengineering Workshop.

Authors:  Kimberly A Kelly; Michael A Hollingsworth; Randall E Brand; Christina H Liu; Vikesh K Singh; Sudhir Srivastava; Ajay D Wasan; Dhiraj Yadav; Dana K Andersen
Journal:  Pancreas       Date:  2015-11       Impact factor: 3.327

4.  Inflammatory potential of diet and risk of pancreatic cancer in the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial.

Authors:  Jiali Zheng; Anwar T Merchant; Michael D Wirth; Jiajia Zhang; Samuel O Antwi; Azza Shoaibi; Nitin Shivappa; Rachael Z Stolzenberg-Solomon; James R Hebert; Susan E Steck
Journal:  Int J Cancer       Date:  2018-02-02       Impact factor: 7.396

5.  Pathogenesis of Pancreatic Cancer-Related Diabetes Mellitus: Quo Vadis?

Authors:  Murray Korc
Journal:  Pancreas       Date:  2019 May/Jun       Impact factor: 3.327

Review 6.  Early Detection of Pancreatic Cancer: Opportunities and Challenges.

Authors:  Aatur D Singhi; Eugene J Koay; Suresh T Chari; Anirban Maitra
Journal:  Gastroenterology       Date:  2019-02-02       Impact factor: 22.682

Review 7.  Interactions between endoplasmic reticulum stress and extracellular vesicles in multiple diseases.

Authors:  Jingyao Ye; Xuehong Liu
Journal:  Front Immunol       Date:  2022-08-11       Impact factor: 8.786
  7 in total

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