Fábio R Silva1, Maria Inês da Rosa2, Bruno R Silva3, Carla Simon4, Maria Cecília Alexandre5, Lidia R Medeiros6, Fabrício S Bitencourt1, Maria Eduarda Fernandes dos Reis7. 1. Medical Residency, São José Hospital, Criciuma, Santa Catarina, Brazil. 2. Postgraduate Program in Health Sciences, Laboratory of Epidemiology, University of Extremo Sul Catarinense, Criciuma, Santa Catarina, Brazil. 3. Medical Residency, Laboratory of Epidemiology, University of Extremo Sul Catarinense, Criciuma, Santa Catarina, Brazil. 4. Scientific Initiation Scholarship FUMDES, Laboratory of Epidemiology, University of Extremo Sul Catarinense, Criciuma, Santa Catarina, Brazil. 5. Scientific Initiation Scholarship PIC 170, Laboratory of Epidemiology, University of Extremo Sul Catarinense, Criciuma, Santa Catarina, Brazil. 6. Postgraduate Program in Medicine, Medical Sciences, Federal University of Rio Grande do Sul, Porto Alegre, Brazil. 7. Veterinary Medical, Laboratory of Epidemiology, University of Extremo Sul Catarinense, Criciuma, Santa Catarina, Brazil.
Abstract
BACKGROUND: The objective of the study was to verify the accuracy of hyperbilirubinaemia as a marker for acute perforated appendicitis. METHODS: A comprehensive search of the MEDLINE (PubMed), EMBASE, Cochrane Central Register of Controlled Trials, IBECS, BIOSIS, Web of Science, SCOPUS, Congress Abstracts and Grey literature from January 1969 to July 2014. We included cross-sectional and cohort studies, prospective and retrospective, which evaluated hyperbilirubinaemia level in perforated appendicitis and compared them with histological analysis of all appendectomy specimens. RESULTS: Eleven studies were analysed, which included 5395 patients. Pooled sensitivity was 54.6% (95% confidence interval (CI), 42.8-65.8) and specificity was 70.0% (95% CI, 54.7-81.9%) using STATA. The diagnostic odds ratio was 2.82 (95% CI, 1.38-5.72%). Summary receiver operating characteristic curves were constructed. The area under the curve was 0.65. CONCLUSION: This meta-analysis showed that the value of hyperbilirubinaemia alone cannot predict acute perforated appendicitis.
BACKGROUND: The objective of the study was to verify the accuracy of hyperbilirubinaemia as a marker for acute perforated appendicitis. METHODS: A comprehensive search of the MEDLINE (PubMed), EMBASE, Cochrane Central Register of Controlled Trials, IBECS, BIOSIS, Web of Science, SCOPUS, Congress Abstracts and Grey literature from January 1969 to July 2014. We included cross-sectional and cohort studies, prospective and retrospective, which evaluated hyperbilirubinaemia level in perforated appendicitis and compared them with histological analysis of all appendectomy specimens. RESULTS: Eleven studies were analysed, which included 5395 patients. Pooled sensitivity was 54.6% (95% confidence interval (CI), 42.8-65.8) and specificity was 70.0% (95% CI, 54.7-81.9%) using STATA. The diagnostic odds ratio was 2.82 (95% CI, 1.38-5.72%). Summary receiver operating characteristic curves were constructed. The area under the curve was 0.65. CONCLUSION: This meta-analysis showed that the value of hyperbilirubinaemia alone cannot predict acute perforated appendicitis.
Authors: Maciej Jastrzębski; Maciej Krasnodębski; Michalina Szczęśniak; Michał Wierzchowski; Julia Pikul; Dariusz Jabłoński; Michał Grąt; Tadeusz Wróblewski; Krzysztof Zieniewicz Journal: Wideochir Inne Tech Maloinwazyjne Date: 2019-08-22 Impact factor: 1.195