Young Ho Lee1, Sang-Cheol Bae2, Gwan Gyu Song3. 1. Division of Rheumatology, Department of Internal Medicine, Korea University College of Medicine, Seoul, South Korea. Electronic address: lyhcgh@korea.ac.kr. 2. Division of Rheumatology, Department of Internal Medicine, The Hospital for Rheumatic Diseases, Hanyang University Medical Center, Seoul, South Korea. 3. Division of Rheumatology, Department of Internal Medicine, Korea University College of Medicine, Seoul, South Korea.
Abstract
OBJECTIVE: We explored whether cytotoxic T lymphocyte antigen-4 (CTLA-4) rs5742909, CD226 rs763361, FAS rs1800682, and FASL rs763110 polymorphisms are associated with rheumatoid arthritis (RA). METHODS: We performed a meta-analysis on the association between the four gene polymorphisms and RA. RESULTS: Nineteen studies were included in the meta-analysis. Meta-analysis of all study subjects showed no association between RA and the CTLA-4 rs5742909 T allele (OR=1.057, 95% CI=0.782-1.429, p=0.719). However, the meta-analysis revealed an association between RA and the CD226 rs763361 T allele in all study subjects (OR=1.294, 95% CI=1.063-1.576, p=0.010), and an association was found between the CD226 rs763361 TT genotype and RA in Asians (OR=1.363, 95% CI=1.126-1.651, p=0.001). Meta-analysis showed no association between RA and the FAS rs1800682 G/A polymorphism. However, meta-analysis revealed an association between RA and the FASL rs763110 T allele in all study subjects (OR=1.366, 95% CI=1.093-1.707, p=0.006) and in Asians (OR=1.402, 95% CI=1.059-1.855, p=0.014). CONCLUSIONS: Our meta-analysis demonstrates that the CD226 rs763361 and FASL rs763110 polymorphisms are associated with RA, especially in Asians.
OBJECTIVE: We explored whether cytotoxic T lymphocyte antigen-4 (CTLA-4) rs5742909, CD226rs763361, FASrs1800682, and FASLrs763110 polymorphisms are associated with rheumatoid arthritis (RA). METHODS: We performed a meta-analysis on the association between the four gene polymorphisms and RA. RESULTS: Nineteen studies were included in the meta-analysis. Meta-analysis of all study subjects showed no association between RA and the CTLA-4rs5742909 T allele (OR=1.057, 95% CI=0.782-1.429, p=0.719). However, the meta-analysis revealed an association between RA and the CD226rs763361 T allele in all study subjects (OR=1.294, 95% CI=1.063-1.576, p=0.010), and an association was found between the CD226rs763361 TT genotype and RA in Asians (OR=1.363, 95% CI=1.126-1.651, p=0.001). Meta-analysis showed no association between RA and the FASrs1800682 G/A polymorphism. However, meta-analysis revealed an association between RA and the FASLrs763110 T allele in all study subjects (OR=1.366, 95% CI=1.093-1.707, p=0.006) and in Asians (OR=1.402, 95% CI=1.059-1.855, p=0.014). CONCLUSIONS: Our meta-analysis demonstrates that the CD226rs763361 and FASLrs763110 polymorphisms are associated with RA, especially in Asians.