Literature DB >> 25644664

Epigenetics and Future Generations.

Lorenzo Del Savio, Michele Loi, Elia Stupka.   

Abstract

Recent evidence of intergenerational epigenetic programming of disease risk broadens the scope of public health preventive interventions to future generations, i.e. non existing people. Due to the transmission of epigenetic predispositions, lifestyles such as smoking or unhealthy diet might affect the health of populations across several generations. While public policy for the health of future generations can be justified through impersonal considerations, such as maximizing aggregate well-being, in this article we explore whether there are rights-based obligations supervening on intergenerational epigenetic programming despite the non-identity argument, which challenges this rationale in case of policies that affect the number and identity of future people. We propose that rights based obligations grounded in the interests of non-existing people might fall upon existing people when generations overlap. In particular, if environmental exposure in F0 (i.e. existing people) will affect the health of F2 (i.e. non-existing people) through epigenetic programming, then F1 (i.e. existing and overlapping with both F0 and F2) might face increased costs to address F2's condition in the future: this might generate obligations upon F0 from various distributive principles, such as the principle of equal opportunity for well being.
© 2015 John Wiley & Sons Ltd.

Entities:  

Keywords:  epigenetics; intergenerational justice; non-identity problem

Mesh:

Year:  2015        PMID: 25644664     DOI: 10.1111/bioe.12150

Source DB:  PubMed          Journal:  Bioethics        ISSN: 0269-9702            Impact factor:   1.898


  5 in total

Review 1.  Non-genomic transmission of longevity between generations: potential mechanisms and evidence across species.

Authors:  Alexander M Vaiserman; Alexander K Koliada; Randy L Jirtle
Journal:  Epigenetics Chromatin       Date:  2017-07-27       Impact factor: 4.954

Review 2.  Transgenerational epigenetics and environmental justice.

Authors:  Mark A Rothstein; Heather L Harrell; Gary E Marchant
Journal:  Environ Epigenet       Date:  2017-08-03

Review 3.  Epigenetics, ethics, law and society: A multidisciplinary review of descriptive, instrumental, dialectical and reflexive analyses.

Authors:  Charles Dupras; Katie Michelle Saulnier; Yann Joly
Journal:  Soc Stud Sci       Date:  2019-08-01       Impact factor: 3.885

4.  Meaning of Ambiguity: A Japanese Survey on Synthetic Biology and Genome Editing.

Authors:  Aiko Hibino; Go Yoshizawa; Jusaku Minari
Journal:  Front Sociol       Date:  2019-12-17

5.  Health, wealth and behavioural change: an exploration of role responsibilities in the wake of epigenetics.

Authors:  Danya F Vears; Flavio D'Abramo
Journal:  J Community Genet       Date:  2017-07-18
  5 in total

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