T D Adams1, A O Hammoud2, L E Davidson3, B Laferrère4, A Fraser5, J B Stanford6, M Hashibe6, J L J Greenwood6, J Kim6, D Taylor7, A J Watson8, K R Smith9, R McKinlay10, S C Simper10, S C Smith10, S C Hunt11. 1. Division of Cardiovascular Genetics, University of Utah and LiVe Well Center Salt Lake, Intermountain Healthcare, Salt Lake City, UT, USA. 2. 1] VF Michigan, Bloomfield Hills, MI, USA [2] Department of Obstetrics and Gynecology, University of Utah, Salt Lake City, UT, USA. 3. 1] Department of Exercise Science, Brigham Young University, Provo, UT, USA [2] Division of Cardiovascular Genetics, University of Utah, Salt Lake City, UT, USA. 4. St Luke's Roosevelt Hospital Center, Columbia University College of Physicians and Surgeons and New York Obesity Nutrition Research Center, Division of Endocrinology, Diabetes and Nutrition, New York, NY, USA. 5. Department of Population Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA. 6. Division of Public Health, University of Utah, Salt Lake City, UT, USA. 7. Homer Warner Center for Informatics Research, Intermountain Healthcare, Salt Lake City, UT, USA. 8. Department of Obstetrics and Gynecology, University of Utah, Salt Lake City, UT, USA. 9. Department of Population Sciences, Huntsman Cancer Institute and Department of Family and Consumer Studies, University of Utah, Salt Lake City, UT, USA. 10. Rocky Mountain Associated Physicians, Inc., Salt Lake City, UT, USA. 11. Division of Cardiovascular Genetics, University of Utah, Salt Lake City, UT, USA.
Abstract
BACKGROUND: Interaction between maternal obesity, intrauterine environment and adverse clinical outcomes of newborns has been described. METHODS: Using statewide birth certificate data, this retrospective, matched-control cohort study compared paired birth weights and complications of infants born to women before and after Roux-en-Y gastric bypass surgery (RYGB) and to matched obese non-operated women in several different groups. Women who had given birth to a child before and after RYGB (group 1; n=295 matches) and women with pregnancies after RYGB (group 2; n=764 matches) were matched to non-operated women based on age, body mass index (BMI) prior to both pregnancy and RYGB, mother's race, year of mother/s birth, date of infant births and birth order. In addition, birth weights of 13 143 live births before and/or after RYGB of their mothers (n=5819) were compared (group 3). RESULTS: Odds ratios (ORs) for having a large-for-gestational-age (LGA) neonate were significantly less after RYGB than for non-surgical mothers: ORs for groups 1 and 2 were 0.19 (0.08-0.38) and 0.33 (0.21-0.51), respectively. In contrast, ORs in all three groups for risk of having a small for gestational age (SGA) neonate were greater for RYGB mothers compared to non-surgical mothers (ORs were 2.16 (1.00-5.04); 2.16 (1.43-3.32); and 2.25 (1.89-2.69), respectively). Neonatal complications were not different for group 1 RYGB and non-surgical women for the first pregnancy following RYGB. Pregnancy-induced hypertension and gestational diabetes were significantly lower for the first pregnancy of mothers following RYGB compared to matched pregnancies of non-surgical mothers. CONCLUSION: Women who had undergone RYGB not only had lower risk for having an LGA neonate compared to BMI-matched mothers, but also had significantly higher risk for delivering an SGA neonate following RYGB. RYGB women were less likely than non-operated women to have pregnancy-related hypertension and diabetes.
BACKGROUND: Interaction between maternal obesity, intrauterine environment and adverse clinical outcomes of newborns has been described. METHODS: Using statewide birth certificate data, this retrospective, matched-control cohort study compared paired birth weights and complications of infants born to women before and after Roux-en-Y gastric bypass surgery (RYGB) and to matched obese non-operated women in several different groups. Women who had given birth to a child before and after RYGB (group 1; n=295 matches) and women with pregnancies after RYGB (group 2; n=764 matches) were matched to non-operated women based on age, body mass index (BMI) prior to both pregnancy and RYGB, mother's race, year of mother/s birth, date of infant births and birth order. In addition, birth weights of 13 143 live births before and/or after RYGB of their mothers (n=5819) were compared (group 3). RESULTS: Odds ratios (ORs) for having a large-for-gestational-age (LGA) neonate were significantly less after RYGB than for non-surgical mothers: ORs for groups 1 and 2 were 0.19 (0.08-0.38) and 0.33 (0.21-0.51), respectively. In contrast, ORs in all three groups for risk of having a small for gestational age (SGA) neonate were greater for RYGB mothers compared to non-surgical mothers (ORs were 2.16 (1.00-5.04); 2.16 (1.43-3.32); and 2.25 (1.89-2.69), respectively). Neonatal complications were not different for group 1 RYGB and non-surgical women for the first pregnancy following RYGB. Pregnancy-induced hypertension and gestational diabetes were significantly lower for the first pregnancy of mothers following RYGB compared to matched pregnancies of non-surgical mothers. CONCLUSION:Women who had undergone RYGB not only had lower risk for having an LGA neonate compared to BMI-matched mothers, but also had significantly higher risk for delivering an SGA neonate following RYGB. RYGB women were less likely than non-operated women to have pregnancy-related hypertension and diabetes.
Authors: Lars Sjöström; Anna-Karin Lindroos; Markku Peltonen; Jarl Torgerson; Claude Bouchard; Björn Carlsson; Sven Dahlgren; Bo Larsson; Kristina Narbro; Carl David Sjöström; Marianne Sullivan; Hans Wedel Journal: N Engl J Med Date: 2004-12-23 Impact factor: 91.245
Authors: Douglas R Thompson; Eva Obarzanek; Debra L Franko; Bruce A Barton; John Morrison; Frank M Biro; Stephen R Daniels; Ruth H Striegel-Moore Journal: J Pediatr Date: 2007-01 Impact factor: 4.406
Authors: Kosisochi M Obinwanne; Kyla A Fredrickson; Michelle A Mathiason; Kara J Kallies; John P Farnen; Shanu N Kothari Journal: J Am Coll Surg Date: 2013-11-01 Impact factor: 6.113
Authors: Jeffrey I Mechanick; Adrienne Youdim; Daniel B Jones; W Timothy Garvey; Daniel L Hurley; M Molly McMahon; Leslie J Heinberg; Robert Kushner; Ted D Adams; Scott Shikora; John B Dixon; Stacy Brethauer Journal: Obesity (Silver Spring) Date: 2013-03 Impact factor: 5.002
Authors: Marcela C Smid; Sarah K Dotters-Katz; Cora-Ann Mcelwain; Eric T Volckmann; Jay Schulkin; Alison M Stuebe Journal: Obes Surg Date: 2017-09 Impact factor: 4.129
Authors: Goele Jans; Christophe Matthys; Sarah Bel; Lieveke Ameye; Matthias Lannoo; Bart Van der Schueren; Bruno Dillemans; Luc Lemmens; Jean-Pierre Saey; Yves van Nieuwenhove; Pascale Grandjean; Ben De Becker; Hilde Logghe; Marc Coppens; Kristien Roelens; Anne Loccufier; Johan Verhaeghe; Roland Devlieger Journal: BMC Pregnancy Childbirth Date: 2016-07-29 Impact factor: 3.007