Synchronization of calcium sulphate cement degradation and new bone formation is improved by external mechanical regulation.

A major challenge faced in the bone materials of weight-bearing without internal fixture support is the mismatch of material degradation and new bone formation, leading to weakening or even failure of the overall bony structure. This study demonstrated in the rat femur model that calcium sulphate cement degradation and new bone formation could be better synchronized by external mechanical force. An ascending force in line with calcium sulphate cement degradation could achieve bone healing in 37 days with ultimate load to failure of 87.00 ± 7.30 N, similar to that of intact femur (80.46 ± 2.79 N, p = 0.369). In contrast, the healing process under either a constant force or no force illustrated significant residual defect volumes of 1.47 ± 0.44 and 4.08 ± 0.89 mm(3) (p < 0.001), and weaker ultimate loads to failure of 69.56 ± 4.74 and 59.17 ± 7.48 N, respectively (p < 0.001). Our results suggest that the mechanical regulation approach deserves further investigation and may potentially offer a clinical strategy to improve synchronization.