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Literature DB >> 25643299

Cocaine-evoked negative symptoms require AMPA receptor trafficking in the lateral habenula.

Frank J Meye¹, Kristina Valentinova¹, Salvatore Lecca¹, Lucile Marion-Poll¹, Matthieu J Maroteaux¹, Stefano Musardo², Imane Moutkine¹, Fabrizio Gardoni², Richard L Huganir³, François Georges⁴, Manuel Mameli¹.

Abstract

Addictive substances mediate positive and negative states promoting persistent drug use. However, substrates for aversive effects of drugs remain elusive. We found that, in mouse lateral habenula (LHb) neurons targeting the rostromedial tegmental nucleus, cocaine enhanced glutamatergic transmission, reduced K(+) currents and increased excitability. GluA1 trafficking in LHb was instrumental for these cocaine-evoked modifications and drug-driven aversive behaviors. Altogether, our results suggest that long-lasting adaptations in LHb shape negative symptoms after drug taking.

Entities: Chemical Disease Gene Mutation Species

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Year: 2015 PMID： 25643299 PMCID： PMC4357267 DOI： 10.1038/nn.3923

Source DB: PubMed Journal: Nat Neurosci ISSN： 1097-6256 Impact factor: 24.884

20 in total

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Authors: Roberto Malinow
Journal: Philos Trans R Soc Lond B Biol Sci Date: 2003-04-29 Impact factor: 6.237

2. βCaMKII in lateral habenula mediates core symptoms of depression.

Authors: Kun Li; Tao Zhou; Lujian Liao; Zhongfei Yang; Catherine Wong; Fritz Henn; Roberto Malinow; John R Yates; Hailan Hu
Journal: Science Date: 2013-08-30 Impact factor: 47.728

3. Postsynaptic receptor trafficking underlying a form of associative learning.

Authors: Simon Rumpel; Joseph LeDoux; Anthony Zador; Roberto Malinow
Journal: Science Date: 2005-03-03 Impact factor: 47.728

4. Lateral habenula as a source of negative reward signals in dopamine neurons.

Authors: Masayuki Matsumoto; Okihide Hikosaka
Journal: Nature Date: 2007-05-23 Impact factor: 49.962

5. The rostromedial tegmental nucleus (RMTg), a GABAergic afferent to midbrain dopamine neurons, encodes aversive stimuli and inhibits motor responses.

Authors: Thomas C Jhou; Howard L Fields; Mark G Baxter; Clifford B Saper; Peter C Holland
Journal: Neuron Date: 2009-03-12 Impact factor: 17.173

6. Enhancing depression mechanisms in midbrain dopamine neurons achieves homeostatic resilience.

Authors: Allyson K Friedman; Jessica J Walsh; Barbara Juarez; Stacy M Ku; Dipesh Chaudhury; Jing Wang; Xianting Li; David M Dietz; Nina Pan; Vincent F Vialou; Rachael L Neve; Zhenyu Yue; Ming-Hu Han
Journal: Science Date: 2014-04-18 Impact factor: 47.728

7. Mechanisms of locomotor sensitization to drugs of abuse in a two-injection protocol.

Authors: Emmanuel Valjent; Jesus Bertran-Gonzalez; Benjamin Aubier; Paul Greengard; Denis Hervé; Jean-Antoine Girault
Journal: Neuropsychopharmacology Date: 2010-01 Impact factor: 7.853

Review 8. A 'crash' course on psychostimulant withdrawal as a model of depression.

Authors: Alasdair M Barr; Athina Markou; Anthony G Phillips
Journal: Trends Pharmacol Sci Date: 2002-10 Impact factor: 14.819

9. Cocaine evokes projection-specific synaptic plasticity of lateral habenula neurons.

Authors: Matthieu Maroteaux; Manuel Mameli
Journal: J Neurosci Date: 2012-09-05 Impact factor: 6.167

Review 10. Synaptic and cellular profile of neurons in the lateral habenula.

Authors: Frank J Meye; Salvatore Lecca; Kristina Valentinova; Manuel Mameli
Journal: Front Hum Neurosci Date: 2013-12-16 Impact factor: 3.169

33 in total

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Authors: Meghan Flanigan; Hossein Aleyasin; Aki Takahashi; Sam A Golden; Scott J Russo
Journal: Pharmacol Biochem Behav Date: 2017-05-10 Impact factor: 3.533

Review 2. The Lateral Habenula Circuitry: Reward Processing and Cognitive Control.

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Journal: J Neurosci Date: 2016-11-09 Impact factor: 6.167

Review 3. G Protein-Gated Potassium Channels: A Link to Drug Addiction.

Authors: Robert A Rifkin; Stephen J Moss; Paul A Slesinger
Journal: Trends Pharmacol Sci Date: 2017-02-07 Impact factor: 14.819

4. Crash course in pallidus-habenula signaling.

Authors: Masago Ishikawa; Paul J Kenny
Journal: Nat Neurosci Date: 2016-07-26 Impact factor: 24.884

Review 5. Circuits and functions of the lateral habenula in health and in disease.

Authors: Hailan Hu; Yihui Cui; Yan Yang
Journal: Nat Rev Neurosci Date: 2020-04-08 Impact factor: 34.870

6. A role for corticotropin-releasing factor signaling in the lateral habenula and its modulation by early-life stress.

Authors: Michael E Authement; Ludovic D Langlois; Ryan D Shepard; Caroline A Browne; Irwin Lucki; Haifa Kassis; Fereshteh S Nugent
Journal: Sci Signal Date: 2018-03-06 Impact factor: 8.192

7. Inhibition of AMPA receptor and CaMKII activity in the lateral habenula reduces depressive-like behavior and alcohol intake in rats.

Authors: Jing Li; Seungwoo Kang; Rao Fu; Liangzhi Wu; Wei Wu; Hongwei Liu; Danielle Gregor; Wanhong Zuo; Alex Bekker; Jiang-Hong Ye
Journal: Neuropharmacology Date: 2017-08-31 Impact factor: 5.250