Literature DB >> 25642981

Is Notch Signaling a Specific Target in Hepatocellular Carcinoma?

Lichun Sun1, Guangchun Sun, Yan Yu, David H Coy.   

Abstract

Hepatocellular carcinoma (HCC) is one of the most malignant cancers, with the second highest cancer death rate world-wide, next to lung cancer. The signaling mechanisms in HCC are currently not clear. Notch signaling, which is highly conserved and plays a critical role in many cancers, was found to be aberrantly upregulated in HCC tissues compared to normal liver tissues. Accumulating evidence supports that Notch signaling plays a significantly important role in HCC carcinogenesis. This review discusses the functions of Notch signaling in HCC and its potential therapeutic applications against this cancer.

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Year:  2015        PMID： 25642981     DOI： 10.2174/1871520615666150202102809

Source DB:  PubMed          Journal:  Anticancer Agents Med Chem        ISSN： 1871-5206            Impact factor:   2.505


  9 in total

1.  HDAC inhibitors suppressed small cell lung cancer cell growth and enhanced the suppressive effects of receptor-targeting cytotoxins via upregulating somatostatin receptor II.

Authors:  Lichun Sun; Quanyong He; Cheguo Tsai; Jun Lei; Jing Chen; Lily Vienna Makcey; David H Coy
Journal:  Am J Transl Res       Date:  2018-02-15       Impact factor: 4.060

2.  Activated Notch signaling augments cell growth in hepatocellular carcinoma via up-regulating the nuclear receptor NR4A2.

Authors:  Bo Zhu; Lichun Sun; Wei Luo; Min Li; David H Coy; Long Yu; Wenbo Yu
Journal:  Oncotarget       Date:  2017-04-04

3.  Knockout of the Nogo-B Gene Attenuates Tumor Growth and Metastasis in Hepatocellular Carcinoma.

Authors:  Bo Zhu; Shaobo Chen; Xiaoding Hu; Xiaofeng Jin; Yichen Le; Lihuan Cao; Zhonghua Yuan; Zhen Lin; Songmin Jiang; Lichun Sun; Long Yu
Journal:  Neoplasia       Date:  2017-06-17       Impact factor: 5.715

4.  Novel Indole-fused benzo-oxazepines (IFBOs) inhibit invasion of hepatocellular carcinoma by targeting IL-6 mediated JAK2/STAT3 oncogenic signals.

Authors:  Ashok K Singh; Archana S Bhadauria; Umesh Kumar; Vinit Raj; Amit Rai; Pranesh Kumar; Amit K Keshari; Dinesh Kumar; Biswanath Maity; Sneha Nath; Anand Prakash; Sudipta Saha
Journal:  Sci Rep       Date:  2018-04-12       Impact factor: 4.379

5.  IPSC‑MSC inhibition assessment in Raw 264.7 cells following oxygen and glucose deprivation reveals a distinct function for cardiopulmonary resuscitation.

Authors:  Yi Yu; Dongping Wang; Hui Li; Yujie Liu; Zhao Xiang; Junlin Wu; Xiaoli Jing
Journal:  Mol Med Rep       Date:  2018-04-11       Impact factor: 2.952

6.  NOTCH target gene HES5 mediates oncogenic and tumor suppressive functions in hepatocarcinogenesis.

Authors:  Sarah Luiken; Angelika Fraas; Matthias Bieg; Raisatun Sugiyanto; Benjamin Goeppert; Stephan Singer; Carolin Ploeger; Gregor Warsow; Jens U Marquardt; Carsten Sticht; Carolina De La Torre; Stefan Pusch; Arianeb Mehrabi; Norbert Gretz; Matthias Schlesner; Roland Eils; Peter Schirmacher; Thomas Longerich; Stephanie Roessler
Journal:  Oncogene       Date:  2020-02-13       Impact factor: 9.867

7.  Expression of Notch family is altered in non‑alcoholic fatty liver disease.

Authors:  Wen-Jin Ding; Wei-Jie Wu; Yuan-Wen Chen; Han-Bei Chen; Jian-Gao Fan; Liang Qiao
Journal:  Mol Med Rep       Date:  2020-06-17       Impact factor: 2.952

8.  Enabled homolog (ENAH) regulated by RNA binding protein splicing factor 3b subunit 4 (SF3B4) exacerbates the proliferation, invasion and migration of hepatocellular carcinoma cells via Notch signaling pathway.

Authors:  Guoming Deng; Yufeng Luo; Yaoming Zhang; Jinfeng Zhang; Zongyun He
Journal:  Bioengineered       Date:  2022-02       Impact factor: 3.269

9.  The Histone Deacetylase Inhibitor Vaproic Acid Induces Cell Growth Arrest in Hepatocellular Carcinoma Cells via Suppressing Notch Signaling.

Authors:  Guangchun Sun; Lily V Mackey; David H Coy; Cui-Yun Yu; Lichun Sun
Journal:  J Cancer       Date:  2015-08-22       Impact factor: 4.207
  9 in total

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