Literature DB >> 25642798

Rationally engineered variants of S-adenosylmethionine (SAM) synthase: reduced product inhibition and synthesis of artificial cofactor homologues.

M Dippe1, W Brandt, H Rost, A Porzel, J Schmidt, L A Wessjohann.   

Abstract

S-Adenosylmethionine (SAM) synthase was engineered for biocatalytic production of SAM and long-chain analogues by rational re-design. Substitution of two conserved isoleucine residues extended the substrate spectrum of the enzyme to artificial S-alkylhomocysteines. The variants proved to be beneficial in preparative synthesis of SAM (and analogues) due to a much reduced product inhibition.

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Year:  2015        PMID： 25642798     DOI： 10.1039/c4cc08478k

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  9 in total

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Authors:  Tyler D Huber; Brooke R Johnson; Jianjun Zhang; Jon S Thorson
Journal:  Curr Opin Biotechnol       Date:  2016-08-06       Impact factor: 9.740

2.  Nucleoside-modified AdoMet analogues for differential methyltransferase targeting.

Authors:  Nicolas V Cornelissen; Freideriki Michailidou; Fabian Muttach; Kristina Rau; Andrea Rentmeister
Journal:  Chem Commun (Camb)       Date:  2020-01-23       Impact factor: 6.222

3.  Biosynthesis of S-Adenosylmethionine by Magnetically Immobilized Escherichia coli Cells Highly Expressing a Methionine Adenosyltransferase Variant.

Authors:  Chunli Yin; Tao Zheng; Xin Chang
Journal:  Molecules       Date:  2017-08-18       Impact factor: 4.411

4.  Analogs of S-Adenosyl-L-Methionine in Studies of Methyltransferases.

Authors:  A Yu Rudenko; S S Mariasina; P V Sergiev; V I Polshakov
Journal:  Mol Biol       Date:  2022-04-14       Impact factor: 1.540

5.  One-Pot Biocatalytic In Vivo Methylation-Hydroamination of Bioderived Lignin Monomers to Generate a Key Precursor to L-DOPA.

Authors:  James L Galman; Fabio Parmeggiani; Lisa Seibt; William R Birmingham; Nicholas J Turner
Journal:  Angew Chem Int Ed Engl       Date:  2022-01-11       Impact factor: 16.823

Review 6.  Methyltransferases: Functions and Applications.

Authors:  Eman Abdelraheem; Benjamin Thair; Romina Fernández Varela; Emely Jockmann; Désirée Popadić; Helen C Hailes; John M Ward; Adolfo M Iribarren; Elizabeth S Lewkowicz; Jennifer N Andexer; Peter-Leon Hagedoorn; Ulf Hanefeld
Journal:  Chembiochem       Date:  2022-07-05       Impact factor: 3.461

Review 7.  Repurposing enzymatic transferase reactions for targeted labeling and analysis of DNA and RNA.

Authors:  Miglė Tomkuvienė; Milda Mickutė; Giedrius Vilkaitis; Saulius Klimašauskas
Journal:  Curr Opin Biotechnol       Date:  2018-10-06       Impact factor: 9.740

8.  Visible-Light Removable Photocaging Groups Accepted by MjMAT Variant: Structural Basis and Compatibility with DNA and RNA Methyltransferases.

Authors:  Aileen Peters; Eric Herrmann; Nicolas V Cornelissen; Nils Klöcker; Daniel Kümmel; Andrea Rentmeister
Journal:  Chembiochem       Date:  2021-10-25       Impact factor: 3.461

9.  Role of the tomato TAGL1 gene in regulating fruit metabolites elucidated using RNA sequence and metabolomics analyses.

Authors:  Xiaodan Zhao; Xinyu Yuan; Sha Chen; Lanhuan Meng; Daqi Fu
Journal:  PLoS One       Date:  2018-06-12       Impact factor: 3.240
  9 in total

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