Martin Demmert1, Anne Schaper1, Julia Pagel1, Corinna Gebauer2, Michael Emeis3, Friedhelm Heitmann4, Angela Kribs5, Jens Siegel6, Dirk Müller7, Annette Keller-Wackerbauer8, Hubert Gerleve9, Christian Wieg10, Egbert Herting1, Wolfgang Göpel1, Christoph Härtel1. 1. Department of Pediatrics, University at Lübeck, Lübeck, Germany. 2. Department of Pediatrics, University of Leipzig, Leipzig, Germany. 3. Department of Neonatology, Vivantes-Klinikum Berlin-Neukölln, Berlin, Germany. 4. Department of Neonatology, Klinikum Dortmund, Dortmund, Germany. 5. Department of Pediatrics, University of Cologne, Köln, Germany. 6. Department of Neonatology, Children´s Hospital Auf der Bult, Hanover, Germany. 7. Department of Neonatology, Klinikum Kassel, Kassel, Germany. 8. Department of Neonatology, Krankenhaus Barmherzige Brüder St. Hedwig, Regensburg, Germany. 9. Department of Neonatology, Klinikum Coesfeld, Coesfeld, Germany. 10. Department of Neonatology, Klinikum Aschaffenburg, Aschaffenburg, Germany.
Abstract
BACKGROUND: To determine whether the secretor gene fucosyltransferase (FUT)2 polymorphism G428A is predictive for adverse outcomes in a large cohort of very-low-birth weight (VLBW) infants. METHODS: We prospectively enrolled 2,406 VLBW infants from the population-based multicenter cohort of the German Neonatal network cohort (2009-2011). The secretor genotype (rs601338) was assessed from DNA samples extracted from buccal swabs. Primary study outcomes were clinical sepsis, blood-culture confirmed sepsis, intracerebral hemorrhage (ICH), necrotizing enterocolitis (NEC) or focal intestinal perforation requiring surgery, and death. RESULTS: Based on the assumption of a recessive genetic model, AA individuals had a higher incidence of ICH (AA: 19.0% vs. GG/AG: 14.9%, P = 0.04) which was not significant in the additive genetic model (multivariable logistic regression analysis; allele carriers: 365 cases, 1,685 controls; OR: 1.2; 95% CI: 0.99-1.4; P = 0.06). Other outcomes were not influenced by FUT2 genotype in either genetic model. CONCLUSION: This large-scale multicenter study did not confirm previously reported associations between FUT2 genotype and adverse outcomes in preterm infants.
BACKGROUND: To determine whether the secretor gene fucosyltransferase (FUT)2 polymorphism G428A is predictive for adverse outcomes in a large cohort of very-low-birth weight (VLBW) infants. METHODS: We prospectively enrolled 2,406 VLBW infants from the population-based multicenter cohort of the German Neonatal network cohort (2009-2011). The secretor genotype (rs601338) was assessed from DNA samples extracted from buccal swabs. Primary study outcomes were clinical sepsis, blood-culture confirmed sepsis, intracerebral hemorrhage (ICH), necrotizing enterocolitis (NEC) or focal intestinal perforation requiring surgery, and death. RESULTS: Based on the assumption of a recessive genetic model, AA individuals had a higher incidence of ICH (AA: 19.0% vs. GG/AG: 14.9%, P = 0.04) which was not significant in the additive genetic model (multivariable logistic regression analysis; allele carriers: 365 cases, 1,685 controls; OR: 1.2; 95% CI: 0.99-1.4; P = 0.06). Other outcomes were not influenced by FUT2 genotype in either genetic model. CONCLUSION: This large-scale multicenter study did not confirm previously reported associations between FUT2 genotype and adverse outcomes in preterm infants.
Authors: Misty Good; Chhinder P Sodhi; Yukihiro Yamaguchi; Hongpeng Jia; Peng Lu; William B Fulton; Laura Y Martin; Thomas Prindle; Diego F Nino; Qinjie Zhou; Congrong Ma; John A Ozolek; Rachael H Buck; Karen C Goehring; David J Hackam Journal: Br J Nutr Date: 2016-09-09 Impact factor: 3.718