| Literature DB >> 25642632 |
Hong Liu1, Astrid Irwanto2, Xi'an Fu3, Gongqi Yu3, Yongxiang Yu3, Yonghu Sun3, Chuan Wang3, Zhenzhen Wang3, Yukinori Okada4, Huiqi Low5, Yi Li5, Herty Liany5, Mingfei Chen3, Fangfang Bao3, Jinghui Li3, Jiabao You3, Qilin Zhang6, Jian Liu3, Tongsheng Chu3, Anand Kumar Andiappan7, Na Wang3, Guiye Niu3, Dianchang Liu3, Xiulu Yu3, Lin Zhang3, Hongqing Tian8, Guizhi Zhou3, Olaf Rotzschke7, Shumin Chen3, Xuejun Zhang9, Jianjun Liu2, Furen Zhang10.
Abstract
Genome-wide association studies (GWAS) have led to the discovery of several susceptibility loci for leprosy with robust evidence, providing biological insight into the role of host genetic factors in mycobacterial infection. However, the identified loci only partially explain disease heritability, and additional genetic risk factors remain to be discovered. We performed a 3-stage GWAS of leprosy in the Chinese population using 8,313 cases and 16,017 controls. Besides confirming all previously published loci, we discovered six new susceptibility loci, and further gene prioritization analysis of these loci implicated BATF3, CCDC88B and CIITA-SOCS1 as new susceptibility genes for leprosy. A systematic evaluation of pleiotropic effects demonstrated a high tendency for leprosy susceptibility loci to show association with autoimmunity and inflammatory diseases. Further analysis suggests that molecular sensing of infection might have a similar pathogenic role across these diseases, whereas immune responses have discordant roles in infectious and inflammatory diseases.Entities:
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Year: 2015 PMID： 25642632 DOI： 10.1038/ng.3212
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330