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Literature DB >> 25641795

Biodegradable nanoellipsoidal artificial antigen presenting cells for antigen specific T-cell activation.

Randall A Meyer¹, Joel C Sunshine, Karlo Perica, Alyssa K Kosmides, Kent Aje, Jonathan P Schneck, Jordan J Green.

Abstract

Non-spherical nanodimensional artificial antigen presenting cells (naAPCs) offer the potential to systemically induce an effective antigen-specific immune response. In this report it is shown biodegradable ellipsoidal naAPCs mimic the T-Cell/APC interaction better than equivalent spherical naAPCs. In addition, it is demonstrated ellipsoidal naAPCs offer reduced non-specific cellular uptake and a superior pharmacokinetic profile compared to spherical naAPCs.

Entities: Chemical

Keywords: CD8+ T-Cell activation; biomimetic; immunoengineering; nanoparticles; particle shape

Mesh：

Substances：
Antigens

Year: 2015 PMID： 25641795 PMCID： PMC4529071 DOI： 10.1002/smll.201402369

Source DB: PubMed Journal: Small ISSN： 1613-6810 Impact factor: 13.281

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