| Literature DB >> 25641432 |
Cédric Rossi1,2, Jérémie Jégu3,4,5,6, Morgane Mounier7, Mylène Dandoit7, Marc Colonna6,8, Laetitia Daubisse-Marliac6,9,10, Brigitte Trétarre6,11, Olivier Ganry6,12, Anne-Valérie Guizard6,13, Simona Bara6,14, Véronique Bouvier6,15, Anne-Sophie Woronoff6,16, Alain Monnereau6,17, Olivier Casasnovas1, Michel Velten3,4,5,6, Xavier Troussard6,18, Marc Maynadié2,6,7.
Abstract
Non-Hodgkin lymphoma (NHL) represents a heterogeneous group of diseases that are known to carry a considerable risk of second primary cancer (SPC). However, little attention has been paid to SPC risk assessment according to NHL subtypes. Data from 10 French population-based cancer registries were used to establish a cohort of 7546 patients with a first diagnosis of NHL (eight subtypes) between 1989 and 2004. Standardized incidence ratios (SIRs) of metachronous SPC were estimated. Among the 7546 patients diagnosed with a NHL, the overall SPC risk was 25% higher than that in the reference population (SIR = 1.25, 95% confidence interval 1.15-1.36). In univariate analysis, the SPC risk differed by lymphoma subtype. Interestingly, multivariate analysis showed that SPC risk did not differ significantly across NHL subtypes after adjustment for the other covariates (p = 0.786). Patients with NHL have an increased risk of SPC that is not influenced by the histological NHL subtype.Entities:
Keywords: Non-Hodgkin lymphoma; epidemiology; risk assessment; second cancer
Mesh：
Year: 2015 PMID： 25641432 DOI： 10.3109/10428194.2015.1007505
Source DB: PubMed Journal: Leuk Lymphoma ISSN： 1026-8022