Jinyan Yang1, Hongxia Li1, Todd Ochs2, Juan Zhao1, Qingyou Zhang1, Shuxu Du3, Yonghong Chen1, Ping Liu1, Yuli Wang1, Xueli Feng1, Chunyu Zhang1, Chaoshu Tang4, Junbao Du5, Hongfang Jin6. 1. Department of Pediatrics, Peking University First Hospital, Beijing, P. R. China. 2. Feinberg School of Medicine, The Ann and Robert Lurie, Children's Hospital, Chicago, IL. 3. Department of Pediatrics, Shijitan Hospital, The Capital Medical University, Beijing, P. R. China. 4. Department of Physiology and Pathophysiology, Peking University Health Sciences Center, Beijing, P. R. China. 5. Department of Pediatrics, Peking University First Hospital, Beijing, P. R. China; Key Laboratory of Cardiovascular Sciences, Ministry of Education, Beijing, P. R. China. 6. Department of Pediatrics, Peking University First Hospital, Beijing, P. R. China. Electronic address: jinhongfang51@126.com.
Abstract
OBJECTIVES: To explore the differences in erythrocyte hydrogen sulfide (H2S) production in children with vasovagal syncope (VVS). STUDY DESIGN: A total of 54 children including 27 with VVS, aged 6-16 years (mean age 11.3 ± 3.3 years), and 27 healthy children, aged 3-17 years (mean age 10.4 ± 1.8 years) were included in the study. Children with VVS had symptoms of dizziness, pallor, blurred vision, nausea, and some had syncope. Erythrocyte H2S production was measured by a sulphur-sensitive electrode. Flow-mediated dilation (FMD) of brachial artery was measured for each patient by vascular ultrasound. RESULTS: H2S production from erythrocytes was significantly increased in the children with VVS compared with controls (P < .01). The erythrocytic H2S production in the VVS-vasoinhibitory subgroup was obviously higher than that in VVS-cardioinhibitory (P < .05) and VVS-mixed inhibitory subgroups (P < .05). FMD in the VVS-vasoinhibitory subgroup was greater than that in the VVS-cardioinhibitory (P < .05) and the VVS-mixed subgroups (P < .05). The erythrocytic H2S production had a positive linear correlation with FMD in children with VVS (P < .05). CONCLUSIONS: Increased erythrocyte H2S production may be involved in the pathogenesis of VVS in children.
OBJECTIVES: To explore the differences in erythrocyte hydrogen sulfide (H2S) production in children with vasovagal syncope (VVS). STUDY DESIGN: A total of 54 children including 27 with VVS, aged 6-16 years (mean age 11.3 ± 3.3 years), and 27 healthy children, aged 3-17 years (mean age 10.4 ± 1.8 years) were included in the study. Children with VVS had symptoms of dizziness, pallor, blurred vision, nausea, and some had syncope. Erythrocyte H2S production was measured by a sulphur-sensitive electrode. Flow-mediated dilation (FMD) of brachial artery was measured for each patient by vascular ultrasound. RESULTS:H2S production from erythrocytes was significantly increased in the children with VVS compared with controls (P < .01). The erythrocytic H2S production in the VVS-vasoinhibitory subgroup was obviously higher than that in VVS-cardioinhibitory (P < .05) and VVS-mixed inhibitory subgroups (P < .05). FMD in the VVS-vasoinhibitory subgroup was greater than that in the VVS-cardioinhibitory (P < .05) and the VVS-mixed subgroups (P < .05). The erythrocytic H2S production had a positive linear correlation with FMD in children with VVS (P < .05). CONCLUSIONS: Increased erythrocyte H2S production may be involved in the pathogenesis of VVS in children.
Authors: Arjan Pol; G Herma Renkema; Albert Tangerman; Edwin G Winkel; Udo F Engelke; Arjan P M de Brouwer; Kent C Lloyd; Renee S Araiza; Lambert van den Heuvel; Heymut Omran; Heike Olbrich; Marijn Oude Elberink; Christian Gilissen; Richard J Rodenburg; Jörn Oliver Sass; K Otfried Schwab; Hendrik Schäfer; Hanka Venselaar; J Silvia Sequeira; Huub J M Op den Camp; Ron A Wevers Journal: Nat Genet Date: 2017-12-18 Impact factor: 38.330