Takahide Arai1, Marie-Claude Morice1, Stephen A O'Connor1, Masanori Yamamoto2,3, Hélène Eltchaninoff4, Alain Leguerrier5, Pascal Leprince6, Marc Laskar7, Bernard Iung8, Jean Fajadet9, Alain Prat10, Michel Lièvre11, Patrick Donzeau-Gouge12, Karine Chevreul2, Emmanuel Teiger2, Thierry Lefèvre1, Martine Gilard13. 1. Department of Cardiology, Institut Cardiovasculaire Paris Sud, Massy, France. 2. Department of Cardiology, Centre Hospitalier Universitaire Henri Mondor, Creteil, France. 3. Department of Cardiology, Toyohashi Heart Center, Aichi, Japan. 4. Department of Cardiology, CHU Rouen, Rouen, France. 5. Department of Cardiovascular Surgery, CHU Rennes, Rennes, France. 6. Department of Cardiovascular Surgery, CHU Pitie-Salpétrière, Paris, France. 7. Department of Cardiology, CHU Dupuytren, Limoges, France. 8. Department of Cardiology, CHU Bichat, Paris, France. 9. Department of Cardiology, Clinique Pasteur, Toulose, France. 10. Department of Cardiovascular Surgery, CHU Lille, Lille, France. 11. Department of Cardiology, University Lyon 1, Lyon, France. 12. Department of Cardiovascular Surgery, Institut Cardiovasculaire Paris Sud, Massy, France. 13. Department of Cardiology, CHU Brest, Brest, France.
Abstract
OBJECTIVES: The relationship between anemia, renal insufficiency, and the outcomes of TAVI patients has not been thoroughly studied. We aimed to evaluate the influence of pre- and post-procedural anemia on the incidence of renal insufficiency, especially AKI, and on the outcomes of TAVI. METHODS: Data from the French national TAVI registry were collected in 3,472 patients who underwent TAVI between January 2010 and December 2012. Of these 2,137 were in the no/mild anemia group, 748 were in the moderate anemia group, and 587 were in the severe anemia group before TAVI. Furthermore, we divided the 3,472 patients into three groups according to post-procedural anemia, measured as post-procedural hemoglobin (Hb) drop: <2 g/dl (n=1,633, group 1), 2 to <4 g/dl (n=1,458, group 2), and >4 g/dl (n = 381, group 3). Procedure and outcome variables were compared. RESULTS: Increased severity of anemia before TAVI was associated with significantly different rates of 1-year mortality (15%, 19%, and 24%, P<0.01), with similar differences in the incidence of AKI (5%, 8%, and 10%, P<0.01). Increased severity of Hb drop was associated with significantly different rates of 1-year mortality (16%, 18%, and 23%, P<0.01), and with similar differences in the incidence of AKI (6%, 7%, and 10%, P=0.04). Both pre- and post-procedural anemia were predictors of the incidence of AKI (OR 1.82, P<0.01; OR 1.82, P<0.01, respectively) and 1-year mortality (HR 1.44, P<0.01; HR 1.50, P<0.01, respectively). CONCLUSIONS: Both pre- and post-procedural anemia were significantly associated AKI and 1-year mortality.
OBJECTIVES: The relationship between anemia, renal insufficiency, and the outcomes of TAVI patients has not been thoroughly studied. We aimed to evaluate the influence of pre- and post-procedural anemia on the incidence of renal insufficiency, especially AKI, and on the outcomes of TAVI. METHODS: Data from the French national TAVI registry were collected in 3,472 patients who underwent TAVI between January 2010 and December 2012. Of these 2,137 were in the no/mild anemia group, 748 were in the moderate anemia group, and 587 were in the severe anemia group before TAVI. Furthermore, we divided the 3,472 patients into three groups according to post-procedural anemia, measured as post-procedural hemoglobin (Hb) drop: <2 g/dl (n=1,633, group 1), 2 to <4 g/dl (n=1,458, group 2), and >4 g/dl (n = 381, group 3). Procedure and outcome variables were compared. RESULTS: Increased severity of anemia before TAVI was associated with significantly different rates of 1-year mortality (15%, 19%, and 24%, P<0.01), with similar differences in the incidence of AKI (5%, 8%, and 10%, P<0.01). Increased severity of Hb drop was associated with significantly different rates of 1-year mortality (16%, 18%, and 23%, P<0.01), and with similar differences in the incidence of AKI (6%, 7%, and 10%, P=0.04). Both pre- and post-procedural anemia were predictors of the incidence of AKI (OR 1.82, P<0.01; OR 1.82, P<0.01, respectively) and 1-year mortality (HR 1.44, P<0.01; HR 1.50, P<0.01, respectively). CONCLUSIONS: Both pre- and post-procedural anemia were significantly associated AKI and 1-year mortality.
Authors: Nevena Zivkovic; Gabby Elbaz-Greener; Feng Qiu; Yaron Arbel; Asim N Cheema; Danny Dvir; Paul Fefer; Ariel Finkelstein; Stephen E Fremes; Sam Radhakrishnan; Josep Rodés-Cabau; Mony Shuvy; Harindra C Wijeysundera Journal: Open Heart Date: 2018-05-30