| Literature DB >> 2564111 |
R L Kradin1, J T Kurnick, D S Lazarus, F I Preffer, S M Dubinett, C E Pinto, J Gifford, E Davidson, B Grove, R J Callahan.
Abstract
Tumour-infiltrating lymphocytes (TIL) were isolated and expanded from small tumour biopsy samples of twenty-eight patients (thirteen with malignant melanoma, seven with renal cell carcinoma, and eight with non-small-cell lung cancer). The patients were treated with autologous expanded TIL (about 10(10)) and continuous infusions of recombinant human interleukin-2(1-3 x 10(6) U/m2 per 24 h). 29% of the patients with renal cell cancer and 23% of those with melanoma achieved objective tumour responses lasting 3-14 months. Toxic side-effects were limited, and no patient required intensive-care monitoring. Adoptive immunotherapy with TIL and interleukin-2 may be an effective systemic approach to the treatment of some patients with malignant melanoma and renal cell carcinoma.Entities:
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Year: 1989 PMID： 2564111 DOI： 10.1016/s0140-6736(89)91609-7
Source DB: PubMed Journal: Lancet ISSN： 0140-6736 Impact factor: 79.321