OBJECTIVE: To investigate the incidence, age of onset and tumor marker levels in benign and malignant pediatric ovarian neoplastic tumors. DESIGN: Retrospective database study. SETTING: Single-center study. POPULATION: Forty-five 0-15-year-old girls operated on for ovarian neoplastic tumors from the beginning of 1999 to the end of 2013. METHODS: Serum alpha-fetoprotein, human chorionic gonadotropin and CA 125 levels as well as follow-up data were recorded from patient charts and tumor histology was re-evaluated. MAIN OUTCOME MEASURES: Incidence of ovarian neoplastic tumors in the pediatric population. Differences in patient characteristics and tumor marker levels between those with benign and malignant tumors. RESULTS: The annual incidence of ovarian tumors was 2.2/100,000 females. Median age at presentation was 13.0 years (range 0.9-15.7), similar in both the 33 (73%) girls with a benign tumor and the 12 (27%) girls with a malignant tumor. The tumors with the highest propensity to metastasize (yolk sac tumors, mixed germ cell tumors, small cell carcinoma) were only found in girls > 9 years. Elevated serum alpha-fetoprotein and CA 125 values associated more often with malignant tumors (p < 0.001 and p < 0.031, respectively). There were no deaths or local recurrences. Four girls with a mature teratoma developed a contralateral benign ovarian tumor during follow up. CONCLUSIONS: Both benign and malignant ovarian tumors are rare in the pediatric population, but the incidence increases with age. High alpha-fetoprotein and CA 125 levels were associated with malignant tumors. The prognosis of the pediatric ovarian tumors seems to be favorable.
OBJECTIVE: To investigate the incidence, age of onset and tumor marker levels in benign and malignant pediatric ovarian neoplastic tumors. DESIGN: Retrospective database study. SETTING: Single-center study. POPULATION: Forty-five 0-15-year-old girls operated on for ovarian neoplastic tumors from the beginning of 1999 to the end of 2013. METHODS: Serum alpha-fetoprotein, human chorionic gonadotropin and CA 125 levels as well as follow-up data were recorded from patient charts and tumor histology was re-evaluated. MAIN OUTCOME MEASURES: Incidence of ovarian neoplastic tumors in the pediatric population. Differences in patient characteristics and tumor marker levels between those with benign and malignant tumors. RESULTS: The annual incidence of ovarian tumors was 2.2/100,000 females. Median age at presentation was 13.0 years (range 0.9-15.7), similar in both the 33 (73%) girls with a benign tumor and the 12 (27%) girls with a malignant tumor. The tumors with the highest propensity to metastasize (yolk sac tumors, mixed germ cell tumors, small cell carcinoma) were only found in girls > 9 years. Elevated serum alpha-fetoprotein and CA 125 values associated more often with malignant tumors (p < 0.001 and p < 0.031, respectively). There were no deaths or local recurrences. Four girls with a mature teratoma developed a contralateral benign ovarian tumor during follow up. CONCLUSIONS: Both benign and malignant ovarian tumors are rare in the pediatric population, but the incidence increases with age. High alpha-fetoprotein and CA 125 levels were associated with malignant tumors. The prognosis of the pediatric ovarian tumors seems to be favorable.
Authors: Amy E Lawrence; Mary E Fallat; Geri Hewitt; Paige Hertweck; Amanda Onwuka; Amin Afrazi; Christina Bence; Robert C Burns; Kristine S Corkum; Patrick A Dillon; Peter F Ehrlich; Jason D Fraser; Dani O Gonzalez; Julia E Grabowski; Rashmi Kabre; Dave R Lal; Matthew P Landman; Charles M Leys; Grace Z Mak; R Elliott Overman; Brooks L Rademacher; Manish T Raiji; Thomas T Sato; Madeline Scannell; Joseph A Sujka; Tiffany Wright; Peter C Minneci; Katherine J Deans; Jennifer H Aldrink Journal: J Pediatr Surg Date: 2019-10-25 Impact factor: 2.545
Authors: Larbi Benradi; Kamal El Haissoufi; Abdelouhab Ammor; Youssef Benmoussa; Imane Kamaoui; Anas Haloui; Amal Bennani; Houssain Benhaddou Journal: Ann Med Surg (Lond) Date: 2021-03-29