Literature DB >> 25637781

Mesencephalic astrocyte-derived neurotrophic factor and cerebral dopamine neurotrophic factor: New endoplasmic reticulum stress response proteins.

Hao Liu1, Xiaolei Tang2, Lei Gong3.   

Abstract

Mesencephalic astrocyte-derived neurotrophic factor (MANF) and cerebral dopamine neurotrophic factor (CDNF) are a novel evolutionary conserved neurotrophic factor (NTF) family. There are two distinct domains in MANF and CDNF 3-dimentional structure, N-terminal saposin-like domain and C-terminal SAP-domain, which suggest their unique mode of action. Although identified for their neurotrophic activity, recent studies have shown MANF and CDNF can protect cells during endoplasmic reticulum (ER) stress. This review summarizes the unique structure and related potential protective role for cells during ER stress of MANF and CDNF.
Copyright © 2015 Elsevier B.V. All rights reserved.

Entities:  

Keywords:  CDNF; ER stress; MANF; NTF

Mesh：

Substances：

Year:  2015        PMID： 25637781     DOI： 10.1016/j.ejphar.2015.01.016

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  11 in total

1.  Cerebral Dopamine Neurotrophic Factor Regulates Multiple Neuronal Subtypes and Behavior.

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Journal:  Herz       Date:  2017-04-25       Impact factor: 1.443

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7.  Photoreceptor Protection by Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF).

Authors:  Jianmin Lu; Lingyu Luo; Deqiang Huang; Xian Liu; Xin Xia; Zhengying Wang; Byron L Lam; Jinglin Yi; Rong Wen; Yiwen Li
Journal:  eNeuro       Date:  2018-04-20

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9.  Astrocytes Attenuate Mitochondrial Dysfunctions in Human Dopaminergic Neurons Derived from iPSC.

Authors:  Fang Du; Qing Yu; Allen Chen; Doris Chen; Shirley ShiDu Yan
Journal:  Stem Cell Reports       Date:  2018-01-27       Impact factor: 7.765

10.  Structural, in silico, and functional analysis of a Disabled-2-derived peptide for recognition of sulfatides.

Authors:  Wei Song; Carter J Gottschalk; Tuo-Xian Tang; Andrew Biscardi; Jeffrey F Ellena; Carla V Finkielstein; Anne M Brown; Daniel G S Capelluto
Journal:  Sci Rep       Date:  2020-08-11       Impact factor: 4.379
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